concept

ITACONATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITACONATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

16Outgoing

2Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ITACONATE

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ITACONATE["ITACONATE"]
    ITACONATE -->|"activates"| NFE2L2["NFE2L2"]
    ITACONATE -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    ITACONATE -->|"downregulates"| IL1B["IL1B"]
    ITACONATE -->|"downregulates"| IL6["IL6"]
    ITACONATE -->|"promotes"| Neurogenesis["Neurogenesis"]
    ITACONATE -->|"treats"| Postoperative_Cognitive_Dysfun["Postoperative Cognitive Dysfunction"]
    ITACONATE -->|"inhibits"| Apoptosis["Apoptosis"]
    ITACONATE -->|"binds"| KEAP1["KEAP1"]
    ACOD1["ACOD1"] -->|"produces"| ITACONATE

Outgoing (16)

Target	Relation	Type	Str
NFE2L2	activates	gene	0.95
Neuroinflammation	inhibits	process	0.92
IL1B	downregulates	gene	0.90
IL6	downregulates	gene	0.90
Postoperative Cognitive Dysfunction	treats	disease	0.88
Neurogenesis	promotes	process	0.88
Apoptosis	inhibits	process	0.87
KEAP1	binds	protein	0.85
NRF2	activates	protein	0.85
inflammation	prevents	process	0.85
KEAP1	inhibits	protein	0.80
NLRP3	modulates	protein	0.80
TFEB	modulates	gene	0.75
inflammatory response	inhibits	process	0.70
neuroinflammation	inhibits	process	0.70
macrophages	regulates	cell_type	0.70

Incoming (2)

Source	Relation	Type	Str
ACOD1	produces	gene	0.90
ACOD1	encodes	gene	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ITACONATE

Understanding Entity Pages

Wiki Pages (5)

Microglia and neuroinflammation in Alzheimer's Disease

NRF2 Activators for Parkinson's Disease

Macroautophagy Dysfunction Validation Framework in Parkinson's Disease