Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RARB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Retinoic Acid Receptor Beta - nuclear receptor critical for neuronal differentiation, synaptic plasticity, and neuroprotection in Alzheimer's and Parkinson's disease
| Gene Symbol | RARB |
| Aliases | Retinoic Acid Receptor Beta |
| Chromosome | 3p24.2 |
| Protein Type | Receptor |
| Function | encodes a nuclear receptor that functions as a ligand-activated transcription factor for retinoic acid (RA), the active metabolite of vitamin A. |
| Primary Expression | numerous tissues including brain, lung, skin, and developing embryonic tissues |
| Amino Acids | 465 aa |
| Exons | 10 |
| Pathways | Notch, Wnt |
| Ensembl ID | ENSG00000177030 |
| GeneCards | RARB |
| Human Protein Atlas | RARB |
| N-terminal activation domain (AF-1) | Contains ligand-independent transcriptional activation function |
| DNA-binding domain (DBD) | Two zinc finger motifs that recognize RAREs in target gene promoters |
| Hinge region | Flexible domain connecting DBD to LBD, contains nuclear localization signals |
| Associated Diseases | neurodegeneration |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["RARB"]
N1["Als"]
N0 -->|"regulates"| N1
N2["Aging"]
N0 -->|"regulates"| N2
N3["Wnt"]
N0 -->|"regulates"| N3
N4["Notch"]
N0 -->|"regulates"| N4
N5["T Cell"]
N0 -->|"regulates"| N5
N6["Igf"]
N0 -->|"regulates"| N6
N7["Rb"]
N0 -->|"regulates"| N7
N8["RNA"]
N8 -->|"regulates"| N0
N9["PRDM4"]
N9 -->|"regulates"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 pathway
class N4 pathway
class N6 protein
class N7 protein
class N8 gene
class N9 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity