gene

RNASEH2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNASEH2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
10Outgoing
5Incoming

Summary

RNASEH2B is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Tumor. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRNASEH2B
Full NameRibonuclease H2 Subunit B
Chromosome13q14.13
Functionis a gene located on chromosome 13q14.
Primary ExpressionUbiquitously expressed; high expression in brain, testis, thyroid
Amino Acids517 aa
Exons14
PathwaysImmune Checkpoint
UniProt IDQ9Y2Q9
NCBI Gene ID79684
Ensembl IDENSG00000137713
OMIM610296
GeneCardsRNASEH2B
Human Protein AtlasRNASEH2B
Associated DiseasesAicardi-Goutières Syndrome
InteractionsTREX1, CD8, STING, DNA, IFN, ARID1A
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RNASEH2B — AlphaFold Q9Y2Q9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

RNASEH2B — Ribonuclease H2 Subunit B

gene · 738 words

RNASEH1 — Ribonuclease H1

gene · 2284 words

R-Loop Stress in Neurodegeneration

mechanism · 1331 words

IFIH1 Gene (MDA5)

gene · 1077 words

RNASEH2A — Ribonuclease H2 Subunit A

gene · 895 words

RNASEH2C — Ribonuclease H2 Subunit C

gene · 591 words

Pathway Diagram

graph TD
    RNASEH2B["<b>RNASEH2B</b>"]
    cytosolic_ssDNA["cytosolic ssDNA"]
    RNASEH2B -.->|"inhibits"| cytosolic_ssDNA
    Tumor{"Tumor"}
    RNASEH2B -->|"activates"| Tumor
    Cancer{"Cancer"}
    RNASEH2B -->|"activates"| Cancer
    Als{"Als"}
    RNASEH2B -->|"activates"| Als
    TREX1(["TREX1"])
    RNASEH2B -->|"activates"| TREX1
    CD8(["CD8"])
    RNASEH2B -->|"activates"| CD8
    ARID1A(["ARID1A"])
    ARID1A -->|"activates"| RNASEH2B
    AND(["AND"])
    AND -->|"activates"| RNASEH2B
    style RNASEH2B fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (10)

TargetRelationTypeStr
cytosolic ssDNAinhibitsphenotype0.90
Tumoractivatesdisease0.65
Canceractivatesdisease0.65
Alsactivatesdisease0.65
TREX1activatesgene0.60

Incoming (5)

SourceRelationTypeStr
ARID1Aactivatesgene0.60
CD8activatesgene0.60
TREX1activatesgene0.60
STINGactivatesgene0.60
ANDactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found