Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RNASEH2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RNASEH2B is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Tumor. Connected to 11 entities in the SciDEX knowledge graph.
| Gene Symbol | RNASEH2B |
| Full Name | Ribonuclease H2 Subunit B |
| Chromosome | 13q14.13 |
| Function | is a gene located on chromosome 13q14. |
| Primary Expression | Ubiquitously expressed; high expression in brain, testis, thyroid |
| Amino Acids | 517 aa |
| Exons | 14 |
| Pathways | Immune Checkpoint |
| UniProt ID | Q9Y2Q9 |
| NCBI Gene ID | 79684 |
| Ensembl ID | ENSG00000137713 |
| OMIM | 610296 |
| GeneCards | RNASEH2B |
| Human Protein Atlas | RNASEH2B |
| Associated Diseases | Aicardi-Goutières Syndrome |
| Interactions | TREX1, CD8, STING, DNA, IFN, ARID1A |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RNASEH2B["<b>RNASEH2B</b>"]
cytosolic_ssDNA["cytosolic ssDNA"]
RNASEH2B -.->|"inhibits"| cytosolic_ssDNA
Tumor{"Tumor"}
RNASEH2B -->|"activates"| Tumor
Cancer{"Cancer"}
RNASEH2B -->|"activates"| Cancer
Als{"Als"}
RNASEH2B -->|"activates"| Als
TREX1(["TREX1"])
RNASEH2B -->|"activates"| TREX1
CD8(["CD8"])
RNASEH2B -->|"activates"| CD8
ARID1A(["ARID1A"])
ARID1A -->|"activates"| RNASEH2B
AND(["AND"])
AND -->|"activates"| RNASEH2B
style RNASEH2B fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| cytosolic ssDNA | inhibits | phenotype | 0.90 |
| Tumor | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| TREX1 | activates | gene | 0.60 |
| CD8 | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| IFN | activates | gene | 0.60 |
| Immune Checkpoint | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||