Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Immune Checkpoint: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Immune Checkpoint |
| Key Genes/Proteins | CANCER |
| Related Diseases | Tumor, Cancer, Als, Breast Cancer, Carcinoma |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
Immune_Checkpoint["<b>Immune Checkpoint</b>"]
CANCER(["CANCER"])
CANCER -.->|"inhibits"| Immune_Checkpoint
Tumor{"Tumor"}
Tumor -->|"therapeutic_target"| Immune_Checkpoint
Cancer{"Cancer"}
Cancer -.->|"inhibits"| Immune_Checkpoint
Als{"Als"}
Als -->|"therapeutic_target"| Immune_Checkpoint
style Immune_Checkpoint fill:#1a3a4a,stroke:#81c784,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Proteins | inhibits | protein | 0.50 |
| WNT SIGNALING | inhibits | concept | 0.50 |
| PD-L1 | inhibits | concept | 0.50 |
| CYTOKINE | activates | concept | 0.50 |
| PD-1/PD-L1 | inhibits | concept | 0.50 |
| CYTOKINE | expressed_in | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | inhibits | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Breast Cancer | inhibits | disease | 1.00 |
| Carcinoma | inhibits | disease | 1.00 |
| Tumor | regulates | disease | 0.90 |
| Colorectal Cancer | therapeutic_target | disease | 0.90 |
| CD8 | activates | gene | 0.90 |
| Lung Cancer | therapeutic_target | disease | 0.90 |
| GENES | therapeutic_target | gene | 0.80 |
| INFLAMMATION | therapeutic_target | gene | 0.80 |
| Inflammation | therapeutic_target | disease | 0.80 |
| AKT | inhibits | gene | 0.80 |
| DNA | regulates | gene | 0.80 |
| DNA | inhibits | gene | 0.80 |
| Inflammation | inhibits | disease | 0.80 |
| KRAS | therapeutic_target | gene | 0.80 |
| Carcinoma | therapeutic_target | disease | 0.80 |
| CANCER | regulates | gene | 0.80 |
| Cancer | regulates | disease | 0.80 |
| CYTOKINES | therapeutic_target | gene | 0.80 |
| KRAS | inhibits | gene | 0.80 |
| Breast Cancer | therapeutic_target | disease | 0.80 |
| Tumor | treats | disease | 0.80 |
| CANCER | treats | gene | 0.70 |
| Cancer | treats | disease | 0.70 |
| Obesity | treats | disease | 0.70 |
| OVERVIEW | therapeutic_target | gene | 0.70 |
| PI3K | inhibits | gene | 0.70 |
| MTOR | inhibits | gene | 0.70 |
| ARID1A | inhibits | gene | 0.70 |
| Als | regulates | disease | 0.70 |
| AUTOPHAGY | therapeutic_target | gene | 0.70 |
| PI3K | therapeutic_target | gene | 0.70 |
| AKT | therapeutic_target | gene | 0.70 |
| TP53 | therapeutic_target | gene | 0.70 |
| APOPTOSIS | therapeutic_target | gene | 0.70 |
| CANCER | implicated_in | gene | 0.70 |
| GENES | implicated_in | gene | 0.70 |
| Cancer | implicated_in | disease | 0.70 |
| Aging | implicated_in | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| White Matter Immune Checkpoint Restoration | 0.418 | neurodegeneration | Gene expression changes in aging mouse b |
| CD300f Immune Checkpoint Activation | 0.366 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular ma [PMID:41053177] | Lin B, Zhou J, Geng D, Chai S, Zhang X e | Cell Death Differ | 2026 | 0 |
| Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107] | Lan T, Shang D, Lin L, Wang H, Zou J et | Autophagy | 2026 | 0 |
| Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814] | Zhang X, Xue J, Zhao C, Zeng C, Zhong J | J Clin Invest | 2026 | 0 |
| Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028] | Yu D, Kang J, Jiang W, Zhang C, Zhao X e | Neuropharmacology | 2026 | 0 |
| Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614] | Li Z, Tan B, Dong K, Yu X, Zhang SW et a | Biochem Pharmacol | 2026 | 0 |
| Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873] | Main BS, Villapol S, Buenaventura RG, Ha | Brain Behav Immun | 2026 | 0 |
| Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781] | Bruna-Jara B, More J, Lobos P, Ponce DP, | Scientific reports | 2026 | 0 |
| Immune checkpoint inhibitor-associated inflammatory arthritis. [PMID:41800958] | Kim ST, Bass AR | Arthritis Rheumatol | 2026 | 0 |
| Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STIN [PMID:41910318] | Yang LM, Lu Y, Levine MS, Wang X, Shi YQ | J Am Chem Soc | 2026 | 0 |
| Primary Infection with Cystoisospora suis Modulates Systemic Immunity and the Gu [PMID:41942044] | Ye X, Huang YJ, Deng XL, He ZY, Tan JJ e | Int J Parasitol | 2026 | 0 |
| CD38 overexpression drives glioblastoma progression via L1CAM/ICAM1/JAK-STAT-Dri [PMID:41946147] | Norouzi S, Aulakh S | Transl Oncol | 2026 | 0 |
| Differential effects of SARS-CoV-2-targeted infection of ATII, club cells, and m [PMID:41951100] | Todd AW, Shein SA, Korchagina AA, Kudino | Mucosal Immunol | 2026 | 0 |
| Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408] | Tian X, Liu J, Li Y, Wang Y, Luo Y, He H | Nature | 2026 | 0 |
| HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707] | da Silva MTT, Araujo AQC | Brain : a journal of neurology | 2026 | 0 |
| Microglia at the Forefront: New Insights From the Glial Club South Cone Meeting [PMID:41668347] | Giambartolomei GH, Iribarren P, Pasquini | J Neurochem | 2026 | 0 |
| Corrigendum to "CD300f enables microglial damage sensing, efferocytosis, and apo [PMID:41734445] | Negro-Demontel L, Evans F, Cawen FA, Fit | Brain, behavior, and immunity | 2026 | 0 |
| IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and [PMID:41790557] | Izawa K, Kaitani A, Enomoto Y, Ando T, Y | Cell Rep | 2026 | 0 |