Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RTN4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RTN4 (Reticulon 4, Nogo) encodes reticulon proteins regulating ER morphology, neurite outgrowth inhibition, and oligodendrocyte biology. Key roles in neurodegeneration through its Nogo-A isoform.
| Gene Symbol | RTN4 |
| Full Name | Reticulon 4 |
| Aliases | NOGO, KIAA0886, NSP |
| Chromosome | 22q11.21 |
| Function | encodes a family of reticulon proteins with three major isoforms: Nogo-A, Nogo-B, and Nogo-C[@schwab2010]. |
| Primary Expression | neurons and oligodendrocytes, where it acts through the Nogo-66 receptor (NgR) and its coreceptor |
| Molecular Weight | 200 kDa |
| Amino Acids | 66 aa |
| Gene Type | Protein Coding |
| Pathways | Autophagy |
| UniProt ID | Q9NPD4 |
| NCBI Gene ID | 57142 |
| Ensembl ID | ENSG00000145113 |
| OMIM | 604569 |
| GeneCards | RTN4 |
| Human Protein Atlas | RTN4 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Interactions | BAI1, AND, BECN1, MAP1LC3B |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RTN4["<b>RTN4</b>"]
Ms{"Ms"}
RTN4 -->|"interacts with"| Ms
neurodegeneration["neurodegeneration"]
RTN4 -->|"implicated in"| neurodegeneration
BAI1["BAI1"]
BAI1 -->|"interacts with"| RTN4
BECN1["BECN1"]
BECN1 -->|"activates"| RTN4
MAP1LC3B["MAP1LC3B"]
MAP1LC3B -->|"activates"| RTN4
style RTN4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | interacts_with | disease | 0.65 |
| BAI1 | interacts_with | gene | 0.60 |
| NOGO | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Angiogenesis | activates | pathway | 0.60 |
| SYNAPSE | regulates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Thalamus | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||