Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SCA7 |
| Full Name | ATXN7 (Ataxin-7) |
| Chromosome | 3p12 |
| Protein Type | Transferase |
| Function | is a 892-amino acid protein with several distinct functional domains |
| Amino Acids | 892 aa |
| Exons | 13 |
| UniProt ID | [Q9UQ50](https://www.uniprot.org/uniprotkb/Q9UQ50/entry) |
| GeneCards | SCA7 |
| Human Protein Atlas | SCA7 |
| Associated Diseases | Ataxia |
| Interactions | ATG12 |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
SCA7(["SCA7"])
Ataxia["Ataxia"]
Neurodegeneration["Neurodegeneration"]
NEURODEGENERATION(["NEURODEGENERATION"])
NEURODEGENERATIVE_DISEASES(["NEURODEGENERATIVE DISEASES"])
neurodegeneration["neurodegeneration"]
SCA7 -->|"associated with"| Ataxia
SCA7 -->|"therapeutic target"| Neurodegeneration
SCA7 -->|"therapeutic target"| NEURODEGENERATION
SCA7 -->|"causes"| NEURODEGENERATIVE_DISEASES
SCA7 -->|"implicated in"| neurodegeneration
style SCA7 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Ataxia | associated_with | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| SPG7 | regulates | gene | 0.60 |
| SPG7 | co_expressed_with | gene | 0.60 |
| neurodegeneration | regulates | disease | 0.60 |
| NEURODEGENERATION | therapeutic_target | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | causes | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||