gene

SPG7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPG7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

Summary

SPG7 encodes paraplegin, a mitochondrial AAA ATPase. Mutations cause autosomal recessive hereditary spastic paraplegia with optic atrophy and cerebellar ataxia.

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🧬 Gene Info

Gene Symbol	SPG7
Full Name	SPG7 — Spastic Paraplegia 7 (Paraplegin)
Chromosome	16q24.3
Protein Type	Gene
Function	is a gene located on chromosome 16q24.
Molecular Weight	88 kDa
Amino Acids	795 aa
Exons	16
GeneCards	SPG7
Human Protein Atlas	SPG7
AFG3L2	functionally related AAA+ protease that cooperates with paraplegin
Hereditary Spastic Paraplegia (HSP)	clinical disorder associated with SPG7 mutations
OPA1	substrate and functional target of SPG7 in mitochondrial dynamics
Mitochondrial Proteostasis	cellular process dependent on SPG7 function
AAA+ ATPases	protein family to which paraplegin belongs
Associated Diseases	Als, Alzheimer, Ms, demyelination, neurodegeneration
Interactions	MAP1LC3A, DDIT3, JUN, TIMM50, HSPA9, TIMM22
KG Connections	101 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SPG7["SPG7"] -->|"associated"| TREM2["TREM2"]
    SPG7["SPG7"] -->|"associated"| neurodegeneration["neurodegeneration"]
    SPG7["SPG7"] -->|"associated"| demyelination["demyelination"]
    SPG7["SPG7"] -.->|"inhibits"| Heart_Failure["Heart Failure"]
    SPG7["SPG7"] -.->|"inhibits"| Ms["Ms"]
    SPG7["SPG7"] -->|"associated"| Alzheimer["Alzheimer"]
    BNIP3["BNIP3"] -.->|"inhibits"| SPG7["SPG7"]
    VDAC1["VDAC1"] -.->|"inhibits"| SPG7["SPG7"]
    FUNDC1["FUNDC1"] -.->|"inhibits"| SPG7["SPG7"]
    TOMM20["TOMM20"] -.->|"inhibits"| SPG7["SPG7"]
    style SPG7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (55)

Target	Relation	Type	Str
Alzheimer Disease	risk_factor_for	disease	0.85
TREM2	associated_with	gene	0.80
neurodegeneration	associated_with	phenotype	0.80
demyelination	associated_with	phenotype	0.80
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
HSPE1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
MAPT	regulates	gene	0.60
LDLR	expressed_in	gene	0.60
ACE	expressed_in	gene	0.60
NDUFS8	regulates	gene	0.60
CLU	regulates	gene	0.60
VCP	associated_with	gene	0.60
STUB1	causes	gene	0.60
VCP	causes	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mitophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
Dna Methylation	expressed_in	pathway	0.60
CYTOKINES	expressed_in	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60

Incoming (46)

Source	Relation	Type	Str
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
OPA1	expressed_in	gene	0.60
CD8	associated_with	gene	0.60
ACE	expressed_in	gene	0.60
NDUFS8	regulates	gene	0.60
LDLR	expressed_in	gene	0.60
CLU	regulates	gene	0.60
MAPT	regulates	gene	0.60
SCA3	regulates	gene	0.60
SCA7	regulates	gene	0.60
SCA3	co_expressed_with	gene	0.60
SCA7	co_expressed_with	gene	0.60
ATXN2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60
RAB32	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
ALZHEIMER DISEASE	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
GENES	regulates	gene	0.60
AND	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SPG7

Understanding Entity Pages

Summary

Wiki Pages (13)

SPG7 (Redirect)

YME1L1 Gene

hereditary-spastic-paraplegia

SPG7 — Spastic Paraplegia 7 (Paraplegin)

Betz Cells

AFG3L2 Gene

KIAA0196 (WASHC5) Gene

Entities

SPG7 Protein — Paraplegin

Upper Motor Neurons in Primary Lateral Sclerosis

C12orf65 - Mitochondrial Release Factor