Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SEL1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SEL1L |
| Full Name | SEL1L E3 Ubiquitin Protein Ligase |
| Aliases | Page for SEL1L |
| Chromosome | 14p31.1 |
| Protein Type | Reductase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 90 kDa |
| Amino Acids | 794 aa |
| Pathways | Er Stress |
| UniProt ID | Q9UHD2 |
| NCBI Gene ID | 6400 |
| Ensembl ID | ENSG00000140451 |
| GeneCards | SEL1L |
| Human Protein Atlas | SEL1L |
| Associated Diseases | Aging, Atherosclerosis |
| Interactions | TIMM17B, EIF2AK3, ERN1, ATF4, HSPA5, MITOCHONDRIAL DYSFUNCTION |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SEL1L["<b>SEL1L</b>"]
Aging{"Aging"}
SEL1L -->|"associated with"| Aging
Atherosclerosis{"Atherosclerosis"}
SEL1L -->|"associated with"| Atherosclerosis
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
SEL1L -->|"activates"| MITOCHONDRIAL_DYSFUNCTION
TIMM17B["TIMM17B"]
SEL1L -->|"activates"| TIMM17B
EIF2AK3["EIF2AK3"]
SEL1L -->|"activates"| EIF2AK3
ERN1["ERN1"]
SEL1L -->|"activates"| ERN1
ATF4["ATF4"]
SEL1L -->|"activates"| ATF4
HSPA5["HSPA5"]
SEL1L -->|"activates"| HSPA5
Er_Stress(["Er Stress"])
SEL1L -->|"activates"| Er_Stress
neurodegeneration["neurodegeneration"]
SEL1L -->|"implicated in"| neurodegeneration
AGING["AGING"]
AGING -->|"associated with"| SEL1L
style SEL1L fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | associated_with | disease | 0.65 |
| Atherosclerosis | associated_with | disease | 0.65 |
| TIMM17B | activates | gene | 0.60 |
| EIF2AK3 | activates | gene | 0.60 |
| ERN1 | activates | gene | 0.60 |
| ATF4 | activates | gene | 0.60 |
| HSPA5 | activates | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.60 |
| Er Stress | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AGING | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||