gene

EIF2AK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2AK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

859Connections

2Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

Page for EIF2AK3 - Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3

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🧬 Gene Info

Gene Symbol	EIF2AK3
Full Name	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3
Aliases	Page for EIF2AK3
Chromosome	2p22.2
Protein Type	Kinase
Function	EIF2AK3 (also known as PERK or EIF2AK1) is an ER transmembrane kinase that initiates the integrated stress response (ISR).
Primary Expression	neurons and glia, with activation in response to ER stress
Molecular Weight	165 kDa
Amino Acids	1448 aa
Pathways	APOPTOSIS, Akt, Apoptosis, Wnt
UniProt ID	[Q9BXJ6](https://www.uniprot.org/uniprot/Q9BXJ6)
Ensembl ID	ENSG00000168269
OMIM	604032
GeneCards	EIF2AK3
Human Protein Atlas	EIF2AK3
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACETYL-COA, Actin, ADSL, AKT, AKT1
SciDEX Hypotheses	Layer-Specific Excitatory Neuron Vulnerability in Oligodendrocyte Stress Response Uniformity
KG Connections	858 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EIF2AK3 - Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3

gene · 703 words

→

EIF2AK3 Protein (PERK)

protein · 1678 words

→

Pathway Diagram

graph TD
    A["ER Stress"] -->|"activates"| B["EIF2AK3/PERK"]
    B -->|"phosphorylates"| C["EIF2S1/eIF2alpha"]
    C -->|"inhibits"| D["General Translation"]
    C -->|"promotes"| E["ATF4"]
    E -->|"activates"| F["CHOP/DDIT3"]
    F -->|"triggers"| G["Apoptosis"]
    B -->|"interacts with"| H["PRKN"]
    B -->|"interacts with"| I["BCL2L11/BIM"]
    I -->|"promotes"| G
    B -->|"interacts with"| J["BNIP3"]
    J -->|"promotes"| G
    F -->|"leads to"| K["Neurodegeneration"]
    G -->|"contributes to"| K
    H -->|"modulates"| L["Mitochondrial Quality"]
    L -->|"dysfunction leads to"| K

Outgoing (566)

Target	Relation	Type	Str
EIF2AK3	encodes	protein	0.00
Endoplasmic Reticulum Stress	activates	process	0.90
autophagy pathway	participates_in	pathway	0.80
ERN1	regulates	gene	0.80
Autophagy	activates	pathway	0.80
autophagy	activates	process	0.80
AUTOPHAGY	activates	gene	0.80
Als	activates	disease	0.75
FIP200	regulates	gene	0.70
Er Stress	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
UNFOLDED PROTEIN RESPONSE	regulates	gene	0.70
MAPK signaling	participates_in	pathway	0.70
necroptosis	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
ER stress	regulates	phenotype	0.70
Demyelination	causes	pathway	0.70
JNK	regulates	gene	0.70
RB1	activates	gene	0.70
LC3	regulates	gene	0.70
NLR	activates	gene	0.70
neural stem cells	activates	cell_type	0.70
ROS	activates	gene	0.70
ER stress response	activates	pathway	0.70
STING1	regulates	gene	0.70
MTORC1	regulates	gene	0.70
NLR	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
neural stem cells	regulates	cell_type	0.70
OPTN	regulates	gene	0.70
RB1	regulates	gene	0.70
NBR1	regulates	gene	0.70
ROS	regulates	gene	0.70
Fibrosis	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cancer	activates	disease	0.65
ALS	regulates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Osteoarthritis	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Arthritis	activates	disease	0.65
Tumor	activates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Neurodegeneration	activates	disease	0.65

Incoming (293)

Source	Relation	Type	Str
EIF2AK3	encodes	gene	0.00
Endoplasmic Reticulum Stress	activates	process	0.90
DNA	regulates	gene	0.70
ERN1	activates	gene	0.70
DDIT3	regulates	gene	0.70
BECN1	activates	gene	0.70
DNA	activates	gene	0.70
ERS	activates	pathway	0.64
OPTN	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
DDIT3	activates	entity	0.60
HSPA5	activates	gene	0.60
DNM1L	interacts_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Layer-Specific Excitatory Neuron Vulnerability in Temporal C	0.636	neurodegeneration	Methodology challenge: dataset 'Allen Br
Oligodendrocyte Stress Response Uniformity	0.455	neuroinflammation	Why do clinical manifestations overlap d