Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIMM17B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TIMM17B is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with Aging, Atherosclerosis, Heart Failure. Connected to 54 entities in the SciDEX knowledge graph.
| Gene Symbol | TIMM17B |
| Full Name | Translocase of Inner Mitochondrial Membrane 17B |
| Chromosome | chrX p21.1 |
| Function | Recognition: Cytosolic chaperones deliver preproteins to the TOM complex |
| Primary Expression | Ubiquitous, high in brain and muscle |
| Molecular Weight | 100 kDa |
| Amino Acids | 170 aa |
| Pathways | Er Stress |
| UniProt ID | O43571 |
| NCBI Gene ID | 10982 |
| Ensembl ID | ENSG00000146592 |
| OMIM | 300260 |
| GeneCards | TIMM17B |
| Human Protein Atlas | TIMM17B |
| TIMM22 | Central channel subunit |
| Associated Diseases | Aging, Atherosclerosis |
| Interactions | OMA1, TIMM23, MTOR, NRF1, HSPD1, MFN2 |
| KG Connections | 53 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TIMM17B["TIMM17B"]
TIMM17B -->|"inhibits"| Heart_Failure["Heart Failure"]
TIMM17B -->|"inhibits"| Ms["Ms"]
TIMM17B -->|"inhibits"| OMA1["OMA1"]
TIMM17B -->|"inhibits"| TIMM23["TIMM23"]
TIMM17B -->|"inhibits"| MTOR["MTOR"]
TIMM17B -->|"inhibits"| NRF1["NRF1"]
TIMM17B -->|"inhibits"| HSPD1["HSPD1"]
TIMM17B -->|"inhibits"| MFN2["MFN2"]
TIMM17B -->|"inhibits"| MFF["MFF"]
TIMM17B -->|"inhibits"| BECN1["BECN1"]
BNIP3["BNIP3"] -->|"inhibits"| TIMM17B
VDAC1["VDAC1"] -->|"inhibits"| TIMM17B
FUNDC1["FUNDC1"] -->|"inhibits"| TIMM17B
TOMM20["TOMM20"] -->|"inhibits"| TIMM17B
TIMM9["TIMM9"] -->|"inhibits"| TIMM17B
SEL1L["SEL1L"] -->|"activates"| TIMM17B
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| TIMM17B| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Atherosclerosis | associated_with | disease | 0.65 |
| OMA1 | inhibits | gene | 0.60 |
| TIMM23 | inhibits | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| NRF1 | inhibits | gene | 0.60 |
| HSPD1 | inhibits | gene | 0.60 |
| MFN2 | inhibits | gene | 0.60 |
| MFF | inhibits | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| LONP1 | inhibits | gene | 0.60 |
| CEBPB | inhibits | gene | 0.60 |
| SPG7 | inhibits | gene | 0.60 |
| MAP1LC3A | inhibits | gene | 0.60 |
| DDIT3 | inhibits | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| TIMM50 | inhibits | gene | 0.60 |
| HSPA9 | inhibits | gene | 0.60 |
| TIMM22 | inhibits | gene | 0.60 |
| HSPE1 | inhibits | gene | 0.60 |
| OPA1 | inhibits | gene | 0.60 |
| LAMP2 | inhibits | gene | 0.60 |
| BNIP3L | inhibits | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| HTRA2 | inhibits | gene | 0.60 |
| PARK2 | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| TIMM17A | inhibits | gene | 0.60 |
| EIF2A | inhibits | gene | 0.60 |
| TFAM | inhibits | gene | 0.60 |
| ULK1 | inhibits | gene | 0.60 |
| TIMM10 | inhibits | gene | 0.60 |
| DNM1L | inhibits | gene | 0.60 |
| EIF2AK3 | activates | gene | 0.60 |
| ERN1 | activates | gene | 0.60 |
| ATF4 | activates | gene | 0.60 |
| HSPA5 | activates | gene | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.60 |
| Unfolded Protein Response | inhibits | pathway | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| Er Stress | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||