gene

HSPA5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

489Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for HSPA5 — Heat Shock Protein Family A (Hsp70) Member 5

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🧬 Gene Info

Gene Symbol	HSPA5
Full Name	Heat Shock Protein Family A (Hsp70) Member 5
Aliases	Hsp70
Chromosome	9q33.3
Protein Family	Hsp70 family (ER-resident)
Protein Type	Chaperone
Function	HSPA5/GRP78 is a BiP (Binding Immunoglobulin Protein) that resides in the ER lumen.
Primary Expression	brain, particularly in neurons and glia
Pathways	Akt, Autophagy, Lipid Metabolism, Wnt
UniProt ID	P11021
NCBI Gene ID	3309
Ensembl ID	ENSG00000156006
OMIM	138120
GeneCards	HSPA5
Human Protein Atlas	HSPA5
Associated Diseases	Aging, Atherosclerosis, Diabetes
Known Drugs/Compounds	rapamycin
Interactions	MAVS, FIP200, AMBRA1, APC, ERN1, EIF2AK3
KG Connections	489 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPA5 — AlphaFold P11021 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HSPA5["HSPA5"] -->|"Interacts With"| Cancer["Cancer"]
    HSPA5["HSPA5"] -->|"Interacts With"| Als["Als"]
    HSPA5["HSPA5"] -->|"Interacts With"| Ms["Ms"]
    HSPA5["HSPA5"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    HSPA5["HSPA5"] -->|"Activates"| Arthritis["Arthritis"]
    HSPA5["HSPA5"] -->|"Interacts With"| MAVS["MAVS"]
    HSPA5["HSPA5"] -->|"Interacts With"| FIP200["FIP200"]
    HSPA5["HSPA5"] -->|"Interacts With"| AMBRA1["AMBRA1"]
    OPTN["OPTN"] -->|"Interacts With"| HSPA5["HSPA5"]
    CASP3["CASP3"] -->|"Interacts With"| HSPA5["HSPA5"]
    AKT1["AKT1"] -->|"Interacts With"| HSPA5["HSPA5"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| HSPA5["HSPA5"]
    CGAS["CGAS"] -->|"Interacts With"| HSPA5["HSPA5"]
    style HSPA5 fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Arthritis fill:#b71c1c,color:#e0e0e0
    style MAVS fill:#8d4900,color:#e0e0e0
    style FIP200 fill:#8d4900,color:#e0e0e0
    style AMBRA1 fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (293)

Target	Relation	Type	Str
ER STRESS	mediates	entity	0.90
JNK	regulates	entity	0.85
EPITHELIUM	expressed_in	entity	0.85
Endoplasmic Reticulum Stress	biomarker_for	process	0.85
APOPTOSIS	inhibits	entity	0.85
OXIDATIVE STRESS	inhibits	entity	0.85
ERK	regulates	entity	0.85
ROS	inhibits	entity	0.85
MAPK	regulates	entity	0.80
THERAPEUTIC_TARGET	therapeutic_target	entity	0.80
ER STRESS	regulates	entity	0.70
NEURODEGENERATION	implicated_in	entity	0.70
APOPTOSIS	regulates	entity	0.70
OXIDATIVE STRESS	modulates	entity	0.70
NEUROINFLAMMATION	mediates	entity	0.70
CANCER	implicated_in	entity	0.70
Arthritis	activates	disease	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Hypertension	expressed_in	disease	0.65
Aging	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
ALS	activates	disease	0.65
Osteoarthritis	activates	disease	0.65
Ovarian Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
MAVS	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
OCLN	therapeutic_target	gene	0.60
IL23A	therapeutic_target	gene	0.60
ERN1	activates	gene	0.60
EIF2AK3	activates	gene	0.60
ATF6	activates	gene	0.60
SQSTM1	interacts_with	gene	0.60

Incoming (196)

Source	Relation	Type	Str
Endoplasmic Reticulum Stress	upregulates	process	0.90
DTG	upregulates	entity	0.90
KDEL	interacts_with	protein	0.85
DDIT3	upregulates	gene	0.80
TFEB	upregulates	entity	0.75
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
CXCL2	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
ATF4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HSPA5

Understanding Entity Pages

Summary

Wiki Pages (21)

HSPA5 — Heat Shock Protein Family A (Hsp70) Member 5

er-stress-neurodegeneration

Unfolded Protein Response (UPR)

RICTOR Protein

TOR1A Gene

PKR Pathway in Neurodegeneration

endoplasmic-reticulum-stress

Shared Proteinostasis Failure in Alzheimer's and Parkinson's Disease

ER Stress in Corticobasal Syndrome

PPP1R15B

H3F3B Gene — H3.3 Histone B

PDIA3 - Protein Disulfide Isomerase Family A Member 3

Proteostasis Network in Neurodegeneration

BIP — Binding Immunoglobulin Protein

CBS ER Stress and Unfolded Protein Response Mechanisms

DNAJB5 (DnaJ Heat Shock Protein Family Member B5)

STX18 - Syntaxin 18

Hsp70/Hsp90 Chaperone Pathway in Parkinson's Disease

ATF6 - Activating Transcription Factor 6