gene 1,705 words KG: SEL1L
Contents

SEL1L - SEL1L E3 Ubiquitin Protein Ligase

🧬 Gene Info
Gene SymbolSEL1L
Full NameSEL1L E3 Ubiquitin Protein Ligase
AliasesPage for SEL1L
Chromosome14p31.1
Protein TypeReductase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight90 kDa
Amino Acids794 aa
PathwaysEr Stress
UniProt IDQ9UHD2
NCBI Gene ID6400
Ensembl IDENSG00000140451
GeneCardsSEL1L
Human Protein AtlasSEL1L
Associated DiseasesAging, Atherosclerosis
InteractionsATF4, EIF2AK3, ERN1, HSPA5, MITOCHONDRIAL DYSFUNCTION, TIMM17B
KG Connections10 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
ATF4 Gene
gene · KG edge: activates
EIF2AK3 - Eukaryotic Translation Initiation Factor 2 Al
gene · KG edge: activates
ERN1 — Endoplasmic Reticulum To Nucleus Signaling 1
gene · KG edge: activates
HSPA5 — Heat Shock Protein Family A (Hsp70) Member 5
gene · KG edge: activates

Knowledge Graph (10 edges)

SEL1L activates TIMM17B
SEL1L activates EIF2AK3
SEL1L activates ERN1
SEL1L activates ATF4
SEL1L activates HSPA5
AGING associated_with SEL1L
SEL1L activates MITOCHONDRIAL DYSFUNCTION
SEL1L associated_with Aging
SEL1L associated_with Atherosclerosis
SEL1L activates Er Stress

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.