gene

SLC44A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC44A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

7Outgoing

6Incoming

Summary

SLC44A2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, expressed in. Associated with Cancer, Cardiovascular, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SLC44A2
Full Name	Solute Carrier Family 44 Member 2
Chromosome	9p21.2
Protein Type	Transporter
Function	encodes a member of the Solute Carrier Family 44.
Primary Expression	various tissues including the brain, blood cells, and epithelial tissues
Pathways	Tgf-Β
UniProt ID	[Q8WWI5](https://www.uniprot.org/uniprot/Q8WWI5)
Ensembl ID	ENSG00000137767
GeneCards	SLC44A2
Human Protein Atlas	SLC44A2
Choline Uptake	SLC44A2 mediates cellular uptake of choline, an essential nutrient.
Phosphatidylcholine Synthesis	Choline is the precursor for phosphatidylcholine biosynthesis, the most abundant phospholipid in mammalian membranes.
Acetylcholine Synthesis	Choline is the precursor for acetylcholine, a key neurotransmitter.
Membrane Maintenance	Choline is required for maintaining membrane integrity and lipid homeostasis.
Associated Diseases	Cardiovascular
Interactions	MUL1, NRP1, UBIQUITIN, CPT2
KG Connections	13 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC44A2["<b>SLC44A2</b>"]
    Cardiovascular{"Cardiovascular"}
    SLC44A2 -->|"associated with"| Cardiovascular
    Ms{"Ms"}
    SLC44A2 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    SLC44A2 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    SLC44A2 -->|"therapeutic target"| Tumor
    RUNX1["RUNX1"]
    SLC44A2 -->|"associated with"| RUNX1
    Tgf__(["Tgf-Beta"])
    SLC44A2 -->|"activates"| Tgf__
    MUL1["MUL1"]
    SLC44A2 -->|"inhibits"| MUL1
    neurodegeneration["neurodegeneration"]
    SLC44A2 -->|"implicated in"| neurodegeneration
    ANG["ANG"]
    ANG -->|"protects against"| SLC44A2
    NRP1["NRP1"]
    NRP1 -->|"activates"| SLC44A2
    APOE["APOE"]
    APOE -->|"associated with"| SLC44A2
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"inhibits"| SLC44A2
    CPT2["CPT2"]
    CPT2 -->|"inhibits"| SLC44A2
    CANCER["CANCER"]
    CANCER -->|"expressed in"| SLC44A2
    style SLC44A2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
Cardiovascular	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
MUL1	inhibits	gene	0.60
RUNX1	associated_with	gene	0.60
Tgf-Β	activates	pathway	0.60

Incoming (6)

Source	Relation	Type	Str
ANG	protects_against	gene	0.60
NRP1	activates	gene	0.60
APOE	associated_with	gene	0.60
UBIQUITIN	inhibits	gene	0.60
CPT2	inhibits	gene	0.60
CANCER	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found