protein

ANG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

266Connections
2Hypotheses
30Analyses
50Outgoing
50Incoming

Summary

ANG is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Cancer, Cardiac. Connected to 149 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolANG
Full NameAngiogenin
AliasesGene profile: ANG
Chromosome14q11.2
Protein TypeProtein
Functionis a multifunctional protein that plays critical roles in both physiological and pathological processes within the nervous system.
Molecular Weight14 kDa
Amino Acids147 aa
Exons2
PathwaysNF-κB
UniProt IDSearch UniProt
GeneCardsANG
Human Protein AtlasANG
MutationLocation
K17ISignal peptide
Associated DiseasesCardiac, Heart Failure, Hypertension, Inflammation, Neuroinflammation
InteractionsKCNK2, NRP1, PIEZO1, PIEZO2, TNF, PDGFRB
KG Connections266 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: ANG — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

ANG — Angiogenin

gene · 2561 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

Ferroptosis in Alzheimer's Disease

mechanism · 4194 words

RNA Metabolism Dysregulation in Alzheimer's Disease

mechanism · 4024 words

Lipid Peroxidation in Neurodegeneration

mechanism · 3848 words

Ferroptosis in Neurodegeneration

mechanism · 3536 words

Pathway Diagram

graph TD
    ANG["<b>ANG</b>"]
    Als{"Als"}
    ANG -->|"inhibits"| Als
    Cardiovascular{"Cardiovascular"}
    ANG -->|"activates"| Cardiovascular
    Inflammation{"Inflammation"}
    ANG -->|"activates"| Inflammation
    Fibrosis{"Fibrosis"}
    ANG -->|"activates"| Fibrosis
    Cardiac{"Cardiac"}
    ANG -->|"activates"| Cardiac
    Ms{"Ms"}
    ANG -->|"activates"| Ms
    ANG -->|"activates"| Als
    Tumor{"Tumor"}
    ANG -->|"activates"| Tumor
    KCNK2["KCNK2"]
    ANG -->|"activates"| KCNK2
    ANG -->|"inhibits"| KCNK2
    NRP1["NRP1"]
    ANG -->|"activates"| NRP1
    APOE["APOE"]
    ANG -->|"associated with"| APOE
    PKC["PKC"]
    PKC -->|"inhibits"| ANG
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| ANG
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| ANG
    CAT["CAT"]
    CAT -->|"activates"| ANG
    ANXA2["ANXA2"]
    ANXA2 -->|"activates"| ANG
    TLR4["TLR4"]
    TLR4 -->|"activates"| ANG
    BCL2["BCL2"]
    BCL2 -->|"activates"| ANG
    style ANG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (182)

TargetRelationTypeStr
Cardiacactivatesdisease0.85
Alsactivatesdisease0.85
Cardiovascularactivatesdisease0.75
Inflammationactivatesdisease0.75
Heart Failureassociated_withdisease0.75

Incoming (84)

SourceRelationTypeStr
PKCinhibitsgene0.60
TRPA1regulatesgene0.60
CATactivatesgene0.60
ANXA2activatesgene0.60
TLR4activatesgene0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Ganglioside Rebalancing Therapy 0.496 neurodegeneration Lipid raft composition changes in synapt
Gap Junction Hemichannel Modulation for Controlled Mitochond 0.386 neurodegeneration Mitochondrial transfer between neurons a

Mentioning Analyses (30)

Scientific analyses that reference this entity

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.544

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

neurodegeneration | 2026-04-15 | 0 hypotheses

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444

How can functional hyperconnectivity patterns distinguish compensatory mechanism

neurodegeneration | 2026-04-13 | 0 hypotheses

What is the actual quantitative contribution of FcRn-mediated transcytosis to BB

neuropharmacology | 2026-04-12 | 1 hypotheses Top: 0.480

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198] Xiao F, Tan X, He A, Zhou Y, Xu K et al. Autophagy 2026 0
Efferocytosis-related biomarkers and immune infiltration in pancreatic ductal ad [PMID:41966742] Huang S, Gu D, Xiong W Biochem Biophys Res Commun 2026 0
Connexin and Pannexin Hemichannels: Broad-Spectrum Players in Neuroinflammatory [PMID:40956013] ["S\u00e1ez J", "Ocaranza F", "Prieto-Vi Journal of neurochemistry 2025 0
Genetic variants in ganglioside synthesis enzymes associate with Alzheimer's dis [PMID:synthetic_29] Unknown Nat Genet 2024 0
CSF ganglioside ratios predict Alzheimer's disease progression and correlate wit [PMID:synthetic_27] Unknown JAMA Neurol 2023 0
Small-molecule modulation of ganglioside synthesis normalizes brain lipid compos [PMID:synthetic_26] Unknown Nat Neurosci 2023 0
Overlap in synaptic neurological condition susceptibility pathways and the neura [PMID:37807670] ["Frederiksen S", "Wicki-Stordeur L", "S Channels (Austin, Tex.) 2023 0
Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect [PMID:35168327] ["Wang D", "Zhang T", "Maduni\u0107 K", Journal of proteome research 2022 0
Brain ganglioside composition is dysregulated in Alzheimer's disease with GM1 de [PMID:synthetic_24] Unknown Ann Neurol 2022 0
GM1 enhances BDNF-TrkB signaling and neuroprotection via lipid raft organization [PMID:synthetic_28] Unknown Mol Psychiatry 2022 0
Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419] Persson RM, Tellnes K, Hoven H, Haaverst Anaesthesia reports 2022 0
GM1 ganglioside reduces amyloid-β aggregation and neurotoxicity in vitro [PMID:synthetic_23] Unknown J Neurosci 2021 0
Ganglioside composition varies widely across brain regions and cell types [PMID:synthetic_32] Unknown J Lipid Res 2021 0
Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270] Fujiya Y, Harada T, Sugawara Y, Akeda Y, Scientific reports 2021 0
Exogenous GM1 administration improves cognition and reduces pathology in APP/PS1 [PMID:synthetic_25] Unknown Neurobiol Aging 2020 0
High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700] Helmuth B, Leichter JJ, Rotjan RD, Casti Scientific data 2020 0
Exogenous GM1 shows limited CNS bioavailability in clinical trials for Parkinson [PMID:synthetic_30] Unknown Mov Disord 2019 0
Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures. [PMID:30862176] ["Scemes E", "Vel\u00ed\u0161ek L", "Vel ASN neuro 2019 0
Ganglioside synthesis inhibitors cause peripheral neuropathy in Gaucher disease [PMID:synthetic_31] Unknown Ann Neurol 2018 0
Expression and function of pannexins in the inner ear and hearing. [PMID:27229462] ["Zhao H"] BMC cell biology 2016 0