gene 1,399 words KG: SLC44A2
Contents

SLC44A2 (CTL2)

🧬 Gene Info
Gene SymbolSLC44A2
Full NameSolute Carrier Family 44 Member 2
Chromosome9p21.2
Protein TypeTransporter
Functionencodes a member of the Solute Carrier Family 44.
Primary Expressionvarious tissues including the brain, blood cells, and epithelial tissues
PathwaysTgf-Β
UniProt ID[Q8WWI5](https://www.uniprot.org/uniprot/Q8WWI5)
Ensembl IDENSG00000137767
GeneCardsSLC44A2
Human Protein AtlasSLC44A2
Choline UptakeSLC44A2 mediates cellular uptake of choline, an essential nutrient.
Phosphatidylcholine SynthesisCholine is the precursor for phosphatidylcholine biosynthesis, the most abundant phospholipid in mammalian membranes.
Acetylcholine SynthesisCholine is the precursor for acetylcholine, a key neurotransmitter.
Membrane MaintenanceCholine is required for maintaining membrane integrity and lipid homeostasis.
Associated DiseasesCardiovascular
InteractionsMUL1, NRP1, UBIQUITIN, CPT2
KG Connections13 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (3)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Ubiquitin
protein · KG edge: inhibits
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
nrp1
gene · KG edge: activates
MUL1 Gene
gene · KG edge: inhibits
CPT2
gene · KG edge: inhibits

Knowledge Graph (12 edges)

SLC44A2 inhibits MUL1
SLC44A2 associated_with RUNX1
SLC44A2 associated_with Cardiovascular
SLC44A2 activates Tgf-Β
SLC44A2 inhibits Ms
SLC44A2 expressed_in Cancer
SLC44A2 therapeutic_target Tumor
ANG protects_against SLC44A2
NRP1 activates SLC44A2
APOE associated_with SLC44A2