pathway

Tgf-Β

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Tgf-Β: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

946Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

Tgf-Β is a biological pathway involved in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 691 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Tgf-Β
Key Genes/Proteins	ABCB1, ABCG2, ACSL4, ACSL5, ACVR2A, adamts4
Related Diseases	aging, Aging
Related Pathways	Akt

Pathway Diagram

graph TD
    Tgf__["Tgf-Beta"] -->|"interacts"| Circadian_Rhythm["Circadian Rhythm"]
    Tgf__["Tgf-Beta"] -->|"interacts"| Mapk["Mapk"]
    Tgf__["Tgf-Beta"] -->|"interacts"| Apoptosis["Apoptosis"]
    Tgf__["Tgf-Beta"] -->|"interacts"| Ferroptosis["Ferroptosis"]
    Tgf__["Tgf-Beta"] -->|"interacts"| Immune_Response["Immune Response"]
    Tgf__["Tgf-Beta"] -->|"interacts"| Innate_Immunity["Innate Immunity"]
    MIRO1["MIRO1"] -->|"associated"| Tgf__["Tgf-Beta"]
    APP["APP"] -->|"therapeutic target"| Tgf__["Tgf-Beta"]
    ST6GAL1["ST6GAL1"] -->|"regulates"| Tgf__["Tgf-Beta"]
    MAX["MAX"] -->|"regulates"| Tgf__["Tgf-Beta"]
    style Tgf__ fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (69)

Target	Relation	Type	Str
MICROGLIA	activates	cell_type	0.90
Neuroinflammation	suppresses	process	0.80
Exosomes	associated_with	entity	0.80
Renal Fibrosis	causes	disease	0.80
MMT	associated_with	process	0.80
Inflammation	modulates	process	0.80
Wound healing	associated_with	process	0.80
M2 anti-inflammatory phenotype	biomarker_for	cell_type	0.70
GBM	associated_with	disease	0.70
glioblastoma multiforme	regulates	disease	0.70
microglial TREM2 activation	modulates	mechanism	0.70
MMP9	activates	protein	0.70
Mtor	interacts_with	pathway	0.55
Innate Immunity	interacts_with	pathway	0.55
Immune Response	interacts_with	pathway	0.55
Circadian Rhythm	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Ferroptosis	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Insulin Signaling	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
COLORECTAL CANCER	inhibits	disease	0.50
HEPATOCELLULAR CARCINOMA	inhibits	disease	0.50
Tgf-Β Signaling	inhibits	pathway	0.50
BAMBI	regulates	concept	0.50
Pi3K/Akt	causes	pathway	0.50
Invasion	causes	pathway	0.50
PI3K/AKT/mTOR	causes	pathway	0.50
PD-L1	activates	concept	0.50
TGFB	activates	gene	0.50
Neurodegenerative Diseases	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
Neuron	regulates	cell_type	0.50
NEURONS	regulates	concept	0.50
Stem Cell	activates	cell_type	0.50
ENDOTHELIAL	activates	concept	0.50
STEM CELLS	activates	concept	0.50
ERBB3	associated_with	concept	0.50
Epithelial-Mesenchymal Transition	associated_with	process	0.50
Proteins	associated_with	protein	0.50
INSULIN	regulates	concept	0.50
IGF-1	regulates	concept	0.50
RAPAMYCIN	regulates	concept	0.50
Macrophage	activates	cell_type	0.50
ANGPT1	activates	concept	0.50
ANGPT1	inhibits	concept	0.50
Invasion	inhibits	pathway	0.50
MACROPHAGES	activates	concept	0.50
disease	associated_with	disease	0.50
Heart Failure	associated_with	disease	0.50

Incoming (877)

Source	Relation	Type	Str
Inflammation	activates	disease	1.00
Cancer	activates	disease	1.00
Inflammation	regulates	disease	1.00
TNF	activates	gene	1.00
CANCER	activates	gene	1.00
Tumor	activates	disease	1.00
Als	therapeutic_target	disease	1.00
CYTOKINES	activates	gene	1.00
INFLAMMATION	inhibits	gene	1.00
Inflammation	inhibits	disease	1.00
INFLAMMATION	regulates	gene	1.00
Als	activates	disease	1.00
TNF-Α	activates	gene	1.00
AKT	associated_with	gene	1.00
PI3K	associated_with	gene	1.00
Tumor	inhibits	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
AKT	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
AUTOPHAGY	activates	gene	1.00
PI3K	inhibits	gene	1.00
Fibrosis	regulates	disease	1.00
AKT	inhibits	gene	1.00
Inflammation	therapeutic_target	disease	1.00
MTOR	activates	gene	1.00
IL-6	activates	gene	1.00
Autoimmune	therapeutic_target	disease	0.90
NEUROINFLAMMATION	activates	gene	0.90
Tumor	therapeutic_target	disease	0.90
Fibrosis	inhibits	disease	0.90
Fibrosis	therapeutic_target	disease	0.90
CYTOKINES	inhibits	gene	0.90
Als	associated_with	disease	0.90
MIRNAS	regulates	gene	0.90
Neurodegeneration	therapeutic_target	disease	0.90
CANCER	therapeutic_target	gene	0.90
APOPTOSIS	activates	gene	0.90
Fibrosis	activates	disease	0.90
ROS	inhibits	gene	0.90
OXIDATIVE STRESS	inhibits	gene	0.90
Neuroinflammation	activates	disease	0.90
Carcinoma	activates	disease	0.90
Britannin	downregulates	compound	0.85
Wnt	interacts_with	pathway	0.80
MTOR	associated_with	gene	0.80
Cancer	inhibits	disease	0.80
MTOR	regulates	gene	0.80
APOPTOSIS	associated_with	gene	0.80
PI3K	activates	gene	0.80

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train	0.712	neuroinflammation	What specific astrocyte-derived factors
TGF-β1-SMAD Signaling Dysregulation	0.380	neurodegeneration	Which specific factors in conditioned me

Mentioning Analyses (1)

Scientific analyses that reference this entity

TREM2 in Alzheimer's Disease: Mechanisms, Therapeutics, and Biomarkers

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.861

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning Tgf-Β in their description or question text

No additional research found