protein

SRCPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRCPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

C Src — Proto Oncogene Tyrosine Protein Kinase Src is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	SRCPROTEIN
Chromosome	20q11.23.
Protein Type	Kinase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	(Zhang et al
Molecular Weight	60 kDa
GeneCards	SRCPROTEIN
Human Protein Atlas	SRCPROTEIN
N-terminal myristoylation site	Gly2 is myristoylated for membrane anchoring
Unique domain (residues 1-80)	Distinguishes c-Src from other SFKs; mediates protein-protein interactions
SH3 domain (residues 84-143)	Binds proline-rich motifs (PXXP); involved in autoinhibition
SH2 domain (residues 150-225)	Binds phosphotyrosine residues; critical for regulatory interactions
C-terminal regulatory tail	Tyr527 (human) is phosphorylated by CSK for autoinhibition
AMPA receptor trafficking	Regulates AMPAR endocytosis and surface expression during long-term depression
PSD-95 interactions	Modifies postsynaptic density scaffolding and receptor clustering
Associated Diseases	AD, ALI, Als, Alzheimer, Autism
Known Drugs/Compounds	DEP, DOP
Interactions	ABL1, ACE, ACSL4, AD, ADRB2, AGING
KG Connections	1076 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

c-Src — Proto-Oncogene Tyrosine-Protein Kinase Src

protein · 997 words

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Pathway Diagram

graph TD
    SRCPROTEIN["SRCPROTEIN"]
    neurodegeneration["neurodegeneration"]
    SRCPROTEIN -->|"implicated_in"| neurodegeneration
    style SRCPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SRCPROTEIN in their description or question text

No additional research found