gene

SRRM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRRM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

25Outgoing

13Incoming

Summary

SRRM2 — Serine/Arginine Repetitive Matrix 2

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🧬 Gene Info

Gene Symbol	SRRM2
Full Name	Serine/Arginine Repetitive Matrix 2
Chromosome	19q13.2
Function	The SRRM2 gene encodes a protein involved in RNA processing and splicing mechanisms critical for neuronal function and survival.
Primary Expression	various brain regions, including the cortex, hippocampus, and spinal cord, where it supports pr
Subcellular Localization	nuclear speckles, subnuclear domains enriched in splicing factors and nascent pre-mRNA transcripts. SRRM2 has emerged as
Pathways	Nuclear Speckle Integrity
UniProt ID	Q9Y5Y9
Ensembl ID	ENSG00000167981
GeneCards	SRRM2
Human Protein Atlas	SRRM2
SRSF1, SRSF2	other SR splicing factors interacting with SRRM2
Spliceosome	molecular machine SRRM2 regulates
FUS, TARDBP	alternative
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Ftd, Ms
Interactions	TDP-43, Poly-GR Protein
KG Connections	38 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SRRM2 — AlphaFold Q9Y5Y9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SRRM2["<b>SRRM2</b>"]
    Als{"Als"}
    SRRM2 -->|"associated with"| Als
    Dementia{"Dementia"}
    SRRM2 -->|"expressed in"| Dementia
    Ms{"Ms"}
    SRRM2 -->|"expressed in"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    SRRM2 -->|"expressed in"| Amyotrophic_Lateral_Sclerosis
    neurodegeneration["neurodegeneration"]
    SRRM2 -->|"implicated in"| neurodegeneration
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"expressed in"| SRRM2
    ALS["ALS"]
    ALS -->|"associated with"| SRRM2
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"expressed in"| SRRM2
    style SRRM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Nuclear Speckle Integrity	involved_in	mechanism	0.87
TDP-43	interacts_with	protein	0.85
Nuclear Speckles	involved_in	cell_type	0.85
TDP-43 Mislocalization	modulates	phenotype	0.80
C9-FTD/ALS	sequestered_in	disease	0.80
Tau aggregates	associated_with	protein	0.70
Als	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Ms	causes	disease	0.65
Ftd	associated_with	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Dementia	causes	disease	0.65
Als	contributes_to	disease	0.65
C9ORF72	causes	gene	0.60
Rb	associated_with	protein	0.60
AND	associated_with	gene	0.60
DEMENTIA	causes	gene	0.60
ALS	associated_with	gene	0.60
RNA	causes	gene	0.60
Neuron	causes	cell_type	0.60
frontotemporal dementia	associated_with	disease	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (13)

Source	Relation	Type	Str
Poly-GR Protein	interacts_with	protein	0.85
Poly-Gr	binds	protein	0.85
C9ORF72	sequesters	gene	0.80
C9ORF72	expressed_in	gene	0.60
C9ORF72	causes	gene	0.60
GR	associated_with	gene	0.60
ALS	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
DEMENTIA	causes	gene	0.60
ALS	contributes_to	gene	0.60
RNA	causes	gene	0.60
RNA SPLICING	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found