Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| JAK | activates | protein | 0.95 |
| Polyphenols | inhibits | compound | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Stathmin-2 Splice Switching to Prevent Axonal Degeneration A | 0.664 | neurodegeneration | RNA binding protein dysregulation across |
| Closed-loop transcranial focused ultrasound to restore hippo | 0.614 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| TREM2 Signaling Bifurcation with Independent TYROBP-Independ | 0.567 | neuroinflammation | Why is TYROBP deficiency neuroprotective |
| Heterogeneous astrocyte activation states differentially imp | 0.523 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
| TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio | 0.499 | neuroinflammation | Why do TAM receptors protect against neu |
| Temporal Microglial State Switching | 0.462 | - | Neuroinflammation and microglial priming |
| IGFBPL1-Mediated Homeostatic Restoration | 0.446 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
epigenetics | 2026-04-15 | 0 hypotheses
neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.552
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and [PMID:39240280] | Miao J, Zhang Y, Su C, Zheng Q, Guo J | Molecular neurobiology | 2025 | 1 |
| IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury b [PMID:40294852] | Li Y, Jiang J, Zhuo Y, Li J, Li Y, Xia Y | Biochimica et biophysica acta. | 2025 | 1 |
| Functional assessments through novel proteomics approaches: Application to insul [PMID:30412730] | Ayyadevara S, Ganne A, Hendrix RD, Balas | Journal of neuroscience method | 2019 | 1 |
| Neuronal functions of FOXO/DAF-16. [PMID:28447066] | Kim SY, Webb AE | Nutrition and healthy aging | 2017 | 1 |
| Caloric restriction. [PMID:21840335] | Speakman JR, Mitchell SE | Molecular aspects of medicine | 2011 | 1 |
| Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pi [PMID:22039242] | Arroba AI, Alvarez-Lindo N, van Rooijen | Investigative ophthalmology & | 2011 | 1 |
| Semaglutide treatment reverses HFD induced hippocampal microglia activation and [PMID:41916100] | ["Gong Haodong", "Liu Junlu", "Wang Yiha | Tissue & cell | 2026 | 0 |
| Brain atrophy patterns in anti-IgLON5 disease. [PMID:40650880] | Yogeshwar SM, Bartels F, Grüter T, Muñiz | Brain | 2026 | 0 |
| Potential diagnostic markers in Alzheimer's disease: current perspectives and fu [PMID:40911035] | Zheng M, Wang S, Jia J | Neurodegener Dis Manag | 2026 | 0 |
| Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyel [PMID:40988129] | Furlan R, Schaedelin S, Frederiksen JL, | Brain | 2026 | 0 |
| Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Commun [PMID:41337685] | Gasparini F, Valletta M, Vetrano DL, Ber | Neurology | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Biomarker-integrated prognostic stagings for Alzheimer's Disease. [PMID:41622252] | Shin D, Lee S, Kim JP, Jang H, Yun J et | Nat Commun | 2026 | 0 |
| Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease an [PMID:41703957] | Özkurt Ç, Kelicen-Uğur P | Biomarkers | 2026 | 0 |
| From scaffold to effector: reframing GFAP in neurodegeneration. [PMID:41775321] | Lu YH, Zhu XP, Li S, Zhang FN, Cai CB et | J Adv Res | 2026 | 0 |
| Translating neurofilament light chain testing into clinical practice: a multidis [PMID:41831326] | Furlan R, Di Sapio A, Ferraro D, Rossi E | Clin Chem Lab Med | 2026 | 0 |
| Role of astrocyte biomarker GFAP in early diagnosis and prognosis assessment of [PMID:41850459] | Li S, Wei S, Wang L, Yu T, Wang H et al. | Int J Biol Macromol | 2026 | 0 |
| Biocompatible Lubricant-Coated Flexible Neural Probes with Enhanced Long-Term Re [PMID:41860566] | Lee H, Lee S, Hwang KS, Kim G, Hong Y et | ACS Appl Bio Mater | 2026 | 0 |
| Ythdf2/Setd1b regulatory axis is essential for cerebellar development through re [PMID:41933071] | Ren X, Jiang J, Hu X, Zhang M, Li J et a | Mol Psychiatry | 2026 | 0 |
| Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348] | Shimasaki R, Kurihara M, Bannai T, Hatan | J Prev Alzheimers Dis | 2026 | 0 |