gene 2,160 words KG: STAT6 2026-03-27
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:neuroinflammation
Contents

STAT6 — Signal Transducer and Activator of Transcription 6

🧬 Gene Info
Gene SymbolSTAT6
Full NameSignal Transducer and Activator of Transcription 6
Chromosome12q13.3
Protein TypeTranscription Factor
Functionis a transcription factor activated specifically by interleukin-4 (IL-4) and interleukin-13 (IL-13) receptor signaling.
Amino Acids847 aa
Gene TypeProtein coding
PathwaysAkt, Apoptosis, Blood-Brain Barrier, Differentiation, Dna Repair
UniProt IDP42262
NCBI Gene ID6778
Ensembl IDENSG00000141510
OMIM601512
GeneCardsSTAT6
Human Protein AtlasSTAT6
Associated DiseasesALS, Asthma, Inflammation, Neuroinflammation
Known Drugs/CompoundsBENVITIMOD, curcumin, Curcumin
InteractionsARNT, JUN, HDAC5, OCLN, AHR, CLDN1
KG Connections321 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: therapeutic_target
BCL2L12 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

STAT6 activates ARNT
STAT6 expressed_in JAK1
STAT6 therapeutic_target OVERVIEW
STAT6 expressed_in STAT3
STAT6 biomarker_for JAK1
STAT6 expressed_in EPHA4
STAT6 expressed_in MERTK
STAT6 therapeutic_target PKC
STAT6 therapeutic_target NRF2
STAT6 activates JUN