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mechanism 1,197 words KG: MAPK/ERK 2026-03-29
kind:mechanismsection:mechanismsstate:published
Contents

MAPK/ERK and JAK-STAT Signaling in 4R-Tauopathies

⚙ Mechanism Info
NameMAPK/ERK
SummaryCross-disease comparison of MAPK/ERK and JAK-STAT stress-responsive signaling pathways across PSP, CBD, AGD, GGT, and FTDP-17
Key Genes/ProteinsTARDBP, NPY, EGR1, SQSTM1/p62, integrins, Trk-B
Related Diseasesreduced loading
Related Pathwaysautophagy

Knowledge Graph

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Related Experiments (8)

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See Also (15)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: inhibitsMAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: activateserk-mapk-signaling-neurodegeneration
mechanism · KG edge: activatesTARDBP — TAR DNA Binding Protein 43
gene · KG edge: phosphorylatesPI3K — Phosphoinositide 3-Kinase
gene · KG edge: inhibits

Knowledge Graph (12 edges)

MAPK/ERK activates EGR1
MAPK/ERK promotes neurodegeneration
MAPK/ERK phosphorylates TARDBP
MAPK/ERK activates Trk-B
autophagy activates MAPK/ERK
SQSTM1/p62 inhibits MAPK/ERK
integrins activates MAPK/ERK
reduced loading inhibits MAPK/ERK
ERK activates MAPK/ERK
MAPK activates MAPK/ERK
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