gene

SYNPO2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNPO2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

8Outgoing

4Incoming

0Experiments

0Debates

Summary

SYNPO2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Als, Ms, Tumor. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SYNPO2
Full Name	Synaptopodin 2
Chromosome	5q33.2
Protein Family	Synaptopodin family
Function	is a member of the synaptopodin family of actin-binding proteins.
Primary Expression	various neuron types, including cortical pyramidal neurons, hippocampal granule cells, and dopaminergic neurons of the substantia nigra
Molecular Weight	130 kDa
Amino Acids	248 aa
Exons	20
UniProt ID	Q9UPM8
Ensembl ID	ENSG00000144671
OMIM	610024
GeneCards	SYNPO2
Human Protein Atlas	SYNPO2
Long isoform (SYNPO2L)	Full-length protein with actin-binding domains
Associated Diseases	neurodegeneration
Interactions	AUTOPHAGY, BAG3, BNIP3, FUNDC1, HSP70, MITOPHAGY
KG Connections	12 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SYNPO2 — AlphaFold Q9UPM8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SYNPO2 — Synaptopodin 2

gene · 1068 words

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Pathway Diagram

graph TD
    SYNPO2["SYNPO2"]
    Als{"Als"}
    SYNPO2 -->|"interacts with"| Als
    Ms{"Ms"}
    SYNPO2 -->|"interacts with"| Ms
    Tumor{"Tumor"}
    SYNPO2 -->|"interacts with"| Tumor
    BAG3["BAG3"]
    SYNPO2 -->|"interacts with"| BAG3
    HSP70["HSP70"]
    SYNPO2 -->|"interacts with"| HSP70
    AUTOPHAGY["AUTOPHAGY"]
    SYNPO2 -->|"interacts with"| AUTOPHAGY
    Autophagy(["Autophagy"])
    SYNPO2 -->|"interacts with"| Autophagy
    Mitophagy(["Mitophagy"])
    SYNPO2 -->|"interacts with"| Mitophagy
    neurodegeneration["neurodegeneration"]
    SYNPO2 -->|"implicated in"| neurodegeneration
    BNIP3["BNIP3"]
    BNIP3 -->|"interacts with"| SYNPO2
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"interacts with"| SYNPO2
    PARKIN["PARKIN"]
    PARKIN -->|"interacts with"| SYNPO2
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"interacts with"| SYNPO2
    style SYNPO2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
AUTOPHAGY	interacts_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Mitophagy	interacts_with	pathway	0.60
BAG3	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60

Incoming (4)

Source	Relation	Type	Str
BNIP3	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SYNPO2 in their description or question text

No additional research found