gene

FUNDC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FUNDC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

951Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

FUNDC1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ALI, ALS. Connected to 405 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolFUNDC1
Full NameFUN14 Domain Containing 1
Chromosome5q33.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight17 kDa
Amino Acids156 aa
Gene TypeProtein coding
PathwaysApoptosis, Autophagy, Ferroptosis, Lipid Metabolism, Metastasis
UniProt IDQ8IWV1
NCBI Gene ID87178
Ensembl IDENSG00000077616
OMIM606467
GeneCardsFUNDC1
Human Protein AtlasFUNDC1
Associated DiseasesAD, ALI, ALS, Alzheimer, Alzheimer's disease
InteractionsAMBRA1, PINK1, BCL2L13, NLRP3, ABCD3, FIP200
KG Connections951 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: FUNDC1 — AlphaFold Q8IWV1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

FUNDC1 — FUN14 Domain Containing 1

gene · 849 words

Mitochondrial Quality Control

mechanism · 5069 words

Mitochondrial Dysfunction in Parkinson's Disease

mechanism · 4972 words

Autophagy Mechanisms

mechanism · 4866 words

Mitophagy Pathway in Neurodegeneration

mechanism · 4637 words

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

clinical · 4511 words

Pathway Diagram

graph TD
    FUNDC1["FUNDC1"] -->|"Participates In"| mitophagy["mitophagy"]
    FUNDC1["FUNDC1"] -->|"Associated With"| BCL2["BCL2"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Dementia["Dementia"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Als["Als"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Parkinson["Parkinson"]
    FUNDC1["FUNDC1"] -->|"Interacts With"| Ms["Ms"]
    CAT["CAT"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    OPTN["OPTN"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    DNM1L["DNM1L"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    CANX["CANX"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    LGALS3["LGALS3"] -->|"Interacts With"| FUNDC1["FUNDC1"]
    style FUNDC1 fill:#8d4900,color:#e0e0e0
    style mitophagy fill:#9C27B0,color:#e0e0e0
    style BCL2 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (625)

TargetRelationTypeStr
GPx4interacts_withprotein0.95
Mitophagyinvolved_inprocess0.95
Hepatic Ischemia-Reperfusion Injurybiomarker_fordisease0.90
mitophagyparticipates_inpathway0.90
Ferroptosisassociated_withprocess0.90

Incoming (326)

SourceRelationTypeStr
MITOPHAGYregulatesgene0.80
LC3interacts_withgene0.70
MITOPHAGYinteracts_withgene0.70
MITOPHAGYactivatesgene0.70
CATinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found