Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FUNDC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FUNDC1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ALI, ALS. Connected to 405 entities in the SciDEX knowledge graph.
| Gene Symbol | FUNDC1 |
| Full Name | FUN14 Domain Containing 1 |
| Chromosome | 5q33.2 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 17 kDa |
| Amino Acids | 156 aa |
| Gene Type | Protein coding |
| Pathways | Apoptosis, Autophagy, Ferroptosis, Lipid Metabolism, Metastasis |
| UniProt ID | Q8IWV1 |
| NCBI Gene ID | 87178 |
| Ensembl ID | ENSG00000077616 |
| OMIM | 606467 |
| GeneCards | FUNDC1 |
| Human Protein Atlas | FUNDC1 |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Alzheimer's disease |
| Interactions | AMBRA1, PINK1, BCL2L13, NLRP3, ABCD3, FIP200 |
| KG Connections | 951 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FUNDC1["FUNDC1"] -->|"Participates In"| mitophagy["mitophagy"]
FUNDC1["FUNDC1"] -->|"Associated With"| BCL2["BCL2"]
FUNDC1["FUNDC1"] -->|"Interacts With"| Dementia["Dementia"]
FUNDC1["FUNDC1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
FUNDC1["FUNDC1"] -->|"Interacts With"| Als["Als"]
FUNDC1["FUNDC1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
FUNDC1["FUNDC1"] -->|"Interacts With"| Parkinson["Parkinson"]
FUNDC1["FUNDC1"] -->|"Interacts With"| Ms["Ms"]
CAT["CAT"] -->|"Interacts With"| FUNDC1["FUNDC1"]
OPTN["OPTN"] -->|"Interacts With"| FUNDC1["FUNDC1"]
DNM1L["DNM1L"] -->|"Interacts With"| FUNDC1["FUNDC1"]
CANX["CANX"] -->|"Interacts With"| FUNDC1["FUNDC1"]
LGALS3["LGALS3"] -->|"Interacts With"| FUNDC1["FUNDC1"]
style FUNDC1 fill:#8d4900,color:#e0e0e0
style mitophagy fill:#9C27B0,color:#e0e0e0
style BCL2 fill:#8d4900,color:#e0e0e0
style Dementia fill:#b71c1c,color:#e0e0e0
style Cardiovascular fill:#b71c1c,color:#e0e0e0
style Als fill:#b71c1c,color:#e0e0e0
style Alzheimer fill:#b71c1c,color:#e0e0e0
style Parkinson fill:#b71c1c,color:#e0e0e0
style Ms fill:#b71c1c,color:#e0e0e0
style CAT fill:#8d4900,color:#e0e0e0
style OPTN fill:#8d4900,color:#e0e0e0
style DNM1L fill:#8d4900,color:#e0e0e0
style CANX fill:#8d4900,color:#e0e0e0
style LGALS3 fill:#8d4900,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| GPx4 | interacts_with | protein | 0.95 |
| Mitophagy | involved_in | process | 0.95 |
| Hepatic Ischemia-Reperfusion Injury | biomarker_for | disease | 0.90 |
| mitophagy | participates_in | pathway | 0.90 |
| Ferroptosis | associated_with | process | 0.90 |
| Liver Fibrosis | contributes_to | disease | 0.85 |
| CCl4-Induced Hepatic Injury | mediates | phenotype | 0.85 |
| MITOPHAGY | mediates | process | 0.85 |
| liver fibrosis | implicated_in | disease | 0.80 |
| Mitophagy | regulates | pathway | 0.80 |
| Liver Fibrosis | biomarker_for | disease | 0.75 |
| Cancer | regulates | disease | 0.75 |
| Cardiovascular | therapeutic_target | disease | 0.75 |
| Cancer | therapeutic_target | disease | 0.75 |
| LC3 | interacts_with | gene | 0.70 |
| BCL2 | associated_with | gene | 0.70 |
| DRP1 | interacts_with | gene | 0.70 |
| DNM1L | interacts_with | gene | 0.70 |
| Mitophagy | interacts_with | pathway | 0.70 |
| Mitophagy | activates | pathway | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| Mitophagy | therapeutic_target | pathway | 0.70 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.70 |
| CANCER | regulates | gene | 0.70 |
| AUTOPHAGY | regulates | gene | 0.70 |
| Er Stress | activates | pathway | 0.70 |
| LC3B | interacts_with | gene | 0.70 |
| MITOCHONDRIA | interacts_with | gene | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| autophagy pathway | participates_in | pathway | 0.70 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| Ischemia | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | interacts_with | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Ftd | interacts_with | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Ischemia | therapeutic_target | disease | 0.65 |
| Cardiac | therapeutic_target | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MITOPHAGY | regulates | gene | 0.80 |
| LC3 | interacts_with | gene | 0.70 |
| MITOPHAGY | interacts_with | gene | 0.70 |
| MITOPHAGY | activates | gene | 0.70 |
| CAT | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| BNIP3 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||