protein 2,968 words KG: TMEM175 2026-03-24
kind:proteinsection:proteinsstate:publishedevidence:strong
Contents

TMEM175 Protein

🔬 Protein Info
Gene SymbolTMEM175
Full NameTMEM175
Protein TypeProtein
Functionis a lysosomal potassium channel that plays critical roles in neuronal function and survival.
Amino Acids522 aa
PathwaysLysosomal pH Homeostasis
UniProt IDSearch UniProt
GeneCardsTMEM175
Human Protein AtlasTMEM175
Associated DiseasesAls, Ms, Neurodegeneration, Parkinson, Parkinson'S Disease
InteractionsJUN, AKT, VCP, PARKINSON, PARKINSON'S DISEASE, LYSOSOME
KG Connections138 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Positioning Dynamics Modulation
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (8)

Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: implicated_in
LAMP2 Gene
gene · KG edge: inhibits
Lysosomal Associated Membrane Protein 1 (LAMP1)
gene · KG edge: associated_with
JUN Gene
gene · KG edge: inhibits
CTSB Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TMEM175 contributes_to LAMP1
TMEM175 associated_with REM sleep behavior disorder
TMEM175 contributes_to TFEB
TMEM175 contributes_to GBA
TMEM175 inhibits JUN
TMEM175 regulates Lysosomal Function
TMEM175 involved_in Lysosomal pH Homeostasis
TMEM175 inhibits AKT
TMEM175 associated_with SMPD1
TMEM175 associated_with CTSD