gene 1,505 words KG: TMEM119 2026-03-26
kind:genesection:genesstate:published
Contents

TMEM119 — Transmembrane Protein 119

🧬 Gene Info
Gene SymbolTMEM119
Full NameTransmembrane Protein 119
AliasesTMEM119 gene page
Chromosome12q14.1
Primary ExpressionCNS Microglia, Bone, Osteoblasts
Molecular Weight47 kDa
Amino Acids386 aa
Exons5
PathwaysCOMPLEMENT, NF-kB signaling, purinergic signaling, senescence, ubiquitin-proteasome
UniProt IDQ2M2W4
NCBI Gene ID344758
Ensembl IDENSG00000145681
OMIM616485
GeneCardsTMEM119
Human Protein AtlasTMEM119
Associated DiseasesALS, Aging, Inflammation, Neuroinflammation
InteractionsNFL, UCHL1, GFAP, UBIQUITIN, C1QB, C1QA
KG Connections230 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (21)

TREM2-Dependent Microglial Senescence Transition
Score: 0.74
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.57
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.56
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52

Related Analyses (12)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (5)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
s:** - GPR32 knockout in microglia should worsen neuroinflam
falsification · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40

See Also (12)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
CD68 Gene
gene · KG edge: biomarker_for
C4B Gene
gene · KG edge: biomarker_for

Knowledge Graph (12 edges)

TMEM119 provides_data_for ds-f2c28aed24a7
TMEM119 expressed_in P2RY12
TMEM119 biomarker_for GAIN
TMEM119 expressed_in TREM2
TMEM119 interacts_with NFL
TMEM119 interacts_with UCHL1
TMEM119 interacts_with GFAP
TMEM119 interacts_with UBIQUITIN
TMEM119 biomarker_for AIF1
TMEM119 associated_with TYROBP