gene 882 words KG: TMEM173
Contents

TMEM173 (STING)

🧬 Gene Info
Gene SymbolTMEM173
Full NameStimulator of Interferon Genes (STING)
Chromosome5q31.2
Protein TypeReceptor
Functionis a critical innate immune receptor that plays a central role in detecting cytosolic DNA and initiating type I interferon responses.
Molecular Weight42 kDa
Amino Acids379 aa
PathwaysNF-κB
UniProt IDQ86WV1
NCBI Gene ID340061
Ensembl IDENSG00000184515
OMIM612374
GeneCardsTMEM173
Human Protein AtlasTMEM173
Associated DiseasesAls, Carcinoma, Ms
InteractionsALOX, AND, APOPTOSIS, ATG, AUTOPHAGY, CANCER
SciDEX HypothesesSTING-Mediated NLRP3 Inflammasome Priming in ALS M
KG Connections131 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Transloc
gene · KG edge: associated_with
ATM Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MAP1LC3B associated_with TMEM173
GPX4 associated_with TMEM173
BMAL1 associated_with TMEM173
LC3 associated_with TMEM173
NCOA4 associated_with TMEM173
ARNTL associated_with TMEM173
CGAS associated_with TMEM173
SLC7A11 associated_with TMEM173
TMEM173 associated_with FANCD2
TMEM173 activates STING1

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