gene 882 words KG: TMEM173 2026-03-24
kind:genesection:genesstate:published
Contents

TMEM173 (STING)

🧬 Gene Info
Gene SymbolTMEM173
Full NameStimulator of Interferon Genes (STING)
Chromosome5q31.2
Protein TypeReceptor
Functionis a critical innate immune receptor that plays a central role in detecting cytosolic DNA and initiating type I interferon responses.
Molecular Weight42 kDa
Amino Acids379 aa
PathwaysNF-κB
UniProt IDQ86WV1
NCBI Gene ID340061
Ensembl IDENSG00000184515
OMIM612374
GeneCardsTMEM173
Human Protein AtlasTMEM173
Encoded ProteinSTING
Associated DiseasesAls, Carcinoma, Ms
InteractionsSTING1, CGAS, STING, TFAM, MAP1LC3B, POLG
KG Connections131 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: activates
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: activates
CGAS Gene
gene · KG edge: activates
BMAL1 (ARNTL) Gene
gene · KG edge: associated_with
ATM Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TMEM173 associated_with FANCD2
TMEM173 activates STING1
TMEM173 associated_with TFAM
TMEM173 associated_with POLG
TMEM173 associated_with ATM
TMEM173 associated_with BMAL1
TMEM173 associated_with ARNTL
TMEM173 associated_with NCOA4
TMEM173 associated_with SLC7A11
TMEM173 associated_with LC3