protein

TREM2-PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREM2-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Debates

Summary

TREM2 Protein — Triggering Receptor Expressed on Myeloid Cells 2

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🔬 Protein Info

Gene Symbol	TREM2
Full Name	PROTEIN
Aliases	Triggering Receptor Expressed on Myeloid cells 2, TREM-2
Chromosome	6p21.1
Protein Type	Receptor
Target Class	Receptor
Function	Lipid sensing; Debris clearance; Microglial activation
Mechanism of Action	Agonist antibodies that enhance TREM2 signaling to promote microglial function
Primary Expression	Microglia, Cerebral cortex, Hippocampus
Druggability	Low (0.42)
Clinical Stage	Phase II
Molecular Weight	35 kDa
Amino Acids	231 aa
Exons	5
Pathways	Innate immunity, Phagocytosis, DAP12-SYK signaling
UniProt ID	Q9NZC2
NCBI Gene ID	54209
Ensembl ID	ENSG00000095970
OMIM	605086
GeneCards	TREM2
Human Protein Atlas	TREM2
Associated Diseases	1-bromopropane neurotoxicity, AD risk, aging, Als
Known Drugs/Compounds	aducanumab, AL002, Al002C, AL002C, Alector AL002, amyloid deposits
Interactions	A2M, AB, ABCA1, ABCA7, ABCG1, ABETA
SciDEX Target	View Target Profile (1 clinical trials)
SciDEX Hypotheses	TREM2-Mediated Astrocyte-Microglia Crosstalk in Ne TREM2-Mediated Microglial Dysfunction Disrupts Per TREM2-Deficient Microglia as Drivers of Amyloid Pl (+117 more)
KG Connections	3820 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TREM2-PROTEIN — AlphaFold Q9NZC2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

flowchart TD
    N0["TREM2 PROTEIN"]
    N1["ALZHEIMER"]
    N0 -->|"activates"| N1
    N2["Alzheimer'S Disease"]
    N0 -->|"activates"| N2
    N3["disease"]
    N0 -->|"activates"| N3
    N4["ALZHEIMER'S"]
    N0 -->|"activates"| N4
    N5["Cortex"]
    N0 -.->|"inhibits"| N5
    N6["Hippocampus"]
    N0 -.->|"inhibits"| N6
    N7["FRONTAL"]
    N0 -.->|"inhibits"| N7
    N8["TREM2"]
    N8 -->|"activates"| N0
    N9["late"]
    N9 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 disease
    class N3 disease
    class N8 gene
    class N9 disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TREM2-PROTEIN in their description or question text

No additional research found