Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUBB2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TUBB2B encodes a neuron-specific beta-tubulin critical for cortical development, neuronal migration, and microtubule function in neurodegeneration.
| Gene Symbol | TUBB2B |
| Full Name | Tubulin Beta 2B Class IIb |
| Chromosome | 6p25.3 |
| Primary Expression | Brain, primarily during development |
| Molecular Weight | ~50 kDa |
| Amino Acids | 445 aa |
| UniProt ID | Q9BUF5 |
| Ensembl ID | ENSG00000159339 |
| GeneCards | TUBB2B |
| Human Protein Atlas | TUBB2B |
| Gene ID (NCBI) | 347733 |
| Protein Length | 445 amino acids |
| Condition | Relationship |
| Periventricular heterotopia | Causal |
| Lissencephaly | Causal |
| Associated Diseases | ALS, Alzheimer, dementia, frontotemporal, neurodegeneration |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TUBB2B["TUBB2B"] -->|"associated_with"| dementia["dementia"]
TUBB2B["TUBB2B"] -->|"associated_with"| neurodegeneration["neurodegeneration"]
TUBB2B["TUBB2B"] -->|"associated_with"| frontotemporal["frontotemporal"]
TUBB2B["TUBB2B"] -->|"associated_with"| Alzheimer["Alzheimer"]
TUBB2B["TUBB2B"] -->|"associated_with"| ALS["ALS"]
SYNPO["SYNPO"] -->|"co_expressed_with"| TUBB2B["TUBB2B"]
TARDBP["TARDBP"] -->|"co_expressed_with"| TUBB2B["TUBB2B"]
style TUBB2B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | associated_with | disease | 0.60 |
| frontotemporal | associated_with | disease | 0.60 |
| dementia | associated_with | disease | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| ALS | associated_with | disease | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CADM1 | implicated_in | gene | 0.60 |
| COMT | implicated_in | gene | 0.60 |
| ITPKA | implicated_in | gene | 0.60 |
| LRFN1 | implicated_in | gene | 0.60 |
| NCAN | implicated_in | gene | 0.60 |
| RAB3B | implicated_in | gene | 0.60 |
| SLC1A2 | implicated_in | gene | 0.60 |
| SYNPO | implicated_in | gene | 0.60 |
| FTLD | implicated_in | gene | 0.60 |
| RNA | implicated_in | gene | 0.60 |
| SYNPO | co_expressed_with | gene | 0.50 |
| TARDBP | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||