gene

SLC1A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC1A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

132Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

SLC1A2 (EAAT2) is the primary glutamate transporter in the brain, responsible for clearing glutamate from the synaptic cleft. Dysfunction of SLC1A2 is strongly implicated in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis throu

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🧬 Gene Info

Gene Symbol	SLC1A2
Full Name	SLC1A2 — Solute Carrier Family 1 Member 2 (EAAT2)
Aliases	EAAT2
Chromosome	11p13
Protein Type	Gene
Function	encodes a protein of 574 amino acids with a molecular weight of approximately 66 kDa.
Primary Expression	astrocytes surrounding synapses, where it plays a critical role in synaptic homeostasis and neuroprotection
Molecular Weight	66 kDa
Amino Acids	574 aa
Exons	19
Pathways	Tdp-43, oxidative stress response, synaptic plasticity, unfolded protein response
NCBI Gene ID	Search NCBI
GeneCards	SLC1A2
Human Protein Atlas	SLC1A2
Associated Diseases	ADHD, ALS, ALZHEIMER'S DISEASE, Alzheimer, Fragile X Syndrome
Interactions	PROGRANULIN, AQP4, GRN, GJA1, APOE, TDP-43
KG Connections	132 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC1A2["SLC1A2"]
    Dementia{"Dementia"}
    SLC1A2 -->|"activates"| Dementia
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    SLC1A2 -->|"activates"| Frontotemporal_Dementia
    Neurodegeneration{"Neurodegeneration"}
    SLC1A2 -->|"activates"| Neurodegeneration
    NEURODEGENERATION["NEURODEGENERATION"]
    SLC1A2 -->|"activates"| NEURODEGENERATION
    ASTROCYTES["ASTROCYTES"]
    SLC1A2 -->|"activates"| ASTROCYTES
    GJA1["GJA1"]
    GJA1 -->|"activates"| SLC1A2
    PROGRANULIN["PROGRANULIN"]
    PROGRANULIN -->|"activates"| SLC1A2
    FTLD["FTLD"]
    FTLD -->|"activates"| SLC1A2
    AQP4["AQP4"]
    AQP4 -->|"activates"| SLC1A2
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| SLC1A2
    GRN["GRN"]
    GRN -->|"activates"| SLC1A2
    AND["AND"]
    AND -->|"activates"| SLC1A2
    NEURON["NEURON"]
    NEURON -->|"activates"| SLC1A2
    APOE["APOE"]
    APOE -->|"activates"| SLC1A2
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"activates"| SLC1A2

Outgoing (75)

Target	Relation	Type	Str
ASTROCYTES	expressed_in	cell_type	0.95
Signal Transmission	involved_in	process	0.90
PARKINSON'S DISEASE	associated_with	disease	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.90
Synaptic Degeneration	suppresses	phenotype	0.85
Neurotransmitter receptor localization	regulates	process	0.80
Glutamate Transport	mediates	process	0.80
Dementia	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Anxiety	activates	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Tauopathy	interacts_with	disease	0.65
glutamate homeostasis	regulates	biological_process	0.60
excitotoxicity	protects_against	biological_process	0.60
seizures	associated_with	phenotype	0.60
febrile seizures	implicated_in	disease	0.60
Fragile X Syndrome	implicated_in	disease	0.60
ADHD	associated_with	disease	0.60
tau hyperphosphorylation	contributes_to	biological_process	0.60
anxiety	associated_with	phenotype	0.60
PROGRANULIN	activates	gene	0.60
AQP4	activates	gene	0.60
GRN	activates	gene	0.60
GJA1	activates	gene	0.60
APOE	activates	gene	0.60
TDP-43	activates	gene	0.60
thalamus	expressed_in	brain_region	0.60
neurodegeneration	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
PSP	interacts_with	gene	0.60
SYNPO	implicated_in	gene	0.60
TUBB2B	implicated_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
Alzheimer's disease	associated_with	disease	0.60
Parkinson's disease	associated_with	disease	0.60
DEMENTIA	activates	gene	0.60
Stem Cell	activates	cell_type	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
ASTROCYTE	activates	gene	0.60
Tdp-43	activates	pathway	0.60
ANXIETY	activates	gene	0.60

Incoming (57)

Source	Relation	Type	Str
YY1	downregulates	gene	0.95
ALKBH5	regulates	protein	0.90
h-019c56c1	targets_gene	hypothesis	0.90
h-019c56c1	targets	hypothesis	0.65
GJA1	activates	gene	0.60
PROGRANULIN	activates	gene	0.60
AQP4	activates	gene	0.60
GRN	activates	gene	0.60
APOE	activates	gene	0.60
Manganese	inhibits	chemical	0.60
YY1	inhibits	protein	0.60
Crocin	activates	chemical	0.60
TDP-43	activates	gene	0.60
APOE	inhibits	gene	0.60
AQP4	inhibits	gene	0.60
GRN	co_discussed	gene	0.60
TAU	transports	gene	0.60
PSMB7	interacts_with	gene	0.60
CADM1	implicated_in	gene	0.60
COMT	implicated_in	gene	0.60
ITPKA	implicated_in	gene	0.60
LRFN1	implicated_in	gene	0.60
NCAN	implicated_in	gene	0.60
RAB3B	implicated_in	gene	0.60
FTLD	activates	gene	0.60
DEMENTIA	activates	gene	0.60
AND	activates	gene	0.60
NEURON	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
NF-κB	regulates	protein	0.60
FMRP	regulates	protein	0.60
ANXIETY	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GABA	activates	gene	0.60
CORTEX	activates	brain_region	0.60
FRONTAL	activates	brain_region	0.60
ASTROCYTE	transports	cell_type	0.60
NEURON	transports	cell_type	0.60
ASTROCYTE	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
FTLD	implicated_in	gene	0.60
GABA	associated_with	gene	0.60
RNA	implicated_in	gene	0.60
GABA	translocates_to	gene	0.60
KCNJ10	activates	gene	0.55
NRF2	activates	gene	0.55
MAPT	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC1A2

Understanding Entity Pages

Summary

Wiki Pages (21)

SLC1A2 — Solute Carrier Family 1 Member 2 (EAAT2)

Novel Therapy Index

Excitotoxicity in Neurodegeneration

Astrocytes

Excitotoxicity Pathway

Glutamate Excitotoxicity Pathway in Neurodegeneration

Tripartite Synapse

Noradrenergic System in Neurodegeneration

TUBB2B — Tubulin Beta 2B Class IIb

LRFN1 — Leucine Rich Repeat and Fibronectin Type III Domain Containing 1

Brain Hyperconnectivity-Tau Spread Hypothesis in Alzheimer's Disease

EAAT2 Glutamate Transporter Rescue Therapy

Glutamatergic Signaling Pathway

Astrocyte Glutamate-Buffer Rescue: EAAT2 Transcription Reboot Therapy

Kir4.1 Potassium Channel (KCNJ10)

Ceftriaxone ALS Trial

Astrocyte Glutamate-Buffer Rescue with EAAT2 Transcription Reboot

Astrocytes in Amyotrophic Lateral Sclerosis

CDKL5 Gene

Astrocyte Dysfunction: AD vs PD vs ALS vs FTD vs HD Comparison