gene

LRFN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRFN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

14Outgoing

5Incoming

Summary

Comprehensive overview of LRFN1 (SALM1) gene, synaptic adhesion molecule functions, role in synapse formation, plasticity, and implications for Alzheimer's disease, schizophrenia, and neurodegenerative disorders.

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🧬 Gene Info

Gene Symbol	LRFN1
Full Name	Leucine Rich Repeat and Fibronectin Type III Domain Containing 1
Aliases	SALM1
Chromosome	19q13.32
Function	is a neuronal synaptic adhesion molecule that plays critical roles in synapse formation, maintenance, and plasticity.
Primary Expression	the central nervous system:
Subcellular Localization	Within neurons, LRFN1 localizes to:
Molecular Weight	75 kDa
UniProt ID	Q9ULJ8
NCBI Gene ID	57608
Ensembl ID	ENSG00000171530
OMIM	610099
GeneCards	LRFN1
Human Protein Atlas	LRFN1
Alternative Names	SALM1, NLRR1
Associated Diseases	ALS, Alzheimer, dementia, frontotemporal, neurodegeneration
KG Connections	19 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LRFN1 — AlphaFold Q9ULJ8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LRFN1["LRFN1"] -->|"associated_with"| dementia["dementia"]
    LRFN1["LRFN1"] -->|"associated_with"| neurodegeneration["neurodegeneration"]
    LRFN1["LRFN1"] -->|"associated_with"| frontotemporal["frontotemporal"]
    LRFN1["LRFN1"] -->|"associated_with"| Alzheimer["Alzheimer"]
    LRFN1["LRFN1"] -->|"associated_with"| ALS["ALS"]
    LRFN1["LRFN1"] -->|"co_expressed_with"| MAPT["MAPT"]
    LRFN1["LRFN1"] -->|"co_expressed_with"| RAB3B["RAB3B"]
    COMT["COMT"] -->|"co_expressed_with"| LRFN1["LRFN1"]
    style LRFN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
neurodegeneration	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
NCAN	implicated_in	gene	0.60
RAB3B	implicated_in	gene	0.60
SLC1A2	implicated_in	gene	0.60
SYNPO	implicated_in	gene	0.60
TUBB2B	implicated_in	gene	0.60
dementia	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
ALS	associated_with	disease	0.60
synaptic plasticity	participates_in	pathway	0.60
RNA	implicated_in	gene	0.60
MAPT	co_expressed_with	gene	0.50
RAB3B	co_expressed_with	gene	0.50

Incoming (5)

Source	Relation	Type	Str
CADM1	implicated_in	gene	0.60
COMT	implicated_in	gene	0.60
ITPKA	implicated_in	gene	0.60
FTLD	implicated_in	gene	0.60
COMT	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found