Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ube2l3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | UBE2L3 |
| Full Name | Ubiquitin-Conjugating Enzyme E2 L3 |
| Chromosome | 22q11.21 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 17.8 kDa |
| Amino Acids | 154 aa |
| Exons | 4 |
| Pathways | cascade: [@pickart2001] |
| NCBI Gene ID | 7332 |
| Ensembl ID | ENSG00000107340 |
| OMIM | 603721 |
| GeneCards | UBE2L3 |
| Human Protein Atlas | UBE2L3 |
| Associated Diseases | neurodegeneration |
| Interactions | OXIDATIVE STRESS, PARK2, PINK1, PRKN, PTEN, UBA1 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["UBE2L3"]
N1["Ms"]
N0 -->|"activates"| N1
N2["Tumor"]
N0 -.->|"inhibits"| N2
N3["OXIDATIVE STRESS"]
N0 -->|"activates"| N3
N4["Oxidative Stress"]
N0 -->|"activates"| N4
N5["Necroptosis"]
N0 -->|"activates"| N5
N6["MLKL"]
N6 -->|"regulates"| N0
N7["neurodegeneration"]
N0 -->|"implicated in"| N7
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 pathway
class N5 pathway
class N6 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Necroptosis | activates | pathway | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:UBE2L3 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity