gene

UBA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

0Analyses

11Outgoing

7Incoming

0Experiments

0Debates

Summary

Page for UBA1 Gene

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🧬 Gene Info

Gene Symbol	UBA1
Aliases	E1 Ubiquitin-Activating Enzyme
Function	Adenylation: UBA1 binds ATP and ubiquitin, forming a ubiquitin-adenylate intermediate
Molecular Weight	117 kDa
Amino Acids	058 aa
Pathways	NF-κB
Ensembl ID	ENSG00000130985
GeneCards	UBA1
Human Protein Atlas	UBA1
Proteasomal degradation	Polyubiquitin chains (K48-linked) target proteins for 26S proteasome degradation
DNA damage response	Monoubiquitination of PCNA and histones regulates repair
[NF-κB](/entities/nf-kb) signaling	Linear and K63-linked ubiquitin chains activate NF-κB
Endosomal sorting	Ubiquitin signals endosomal trafficking via ESCRT pathway
Cell cycle regulation	Ubiquitin-dependent degradation of cyclins and cell cycle inhibitors
UBA1a (117 kDa)	Full-length, nuclear-localized; initiates from Met1
Associated Diseases	Senescence
Interactions	AGING, INFLAMMATION, NLRP3, PARK2, PINK1, PRKN
KG Connections	18 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    UBA1(["UBA1"])
    Aging["Aging"]
    Cancer["Cancer"]
    Inflammation["Inflammation"]
    Senescence["Senescence"]
    AND(["AND"])
    AGING(["AGING"])
    INFLAMMATION(["INFLAMMATION"])
    neurodegeneration["neurodegeneration"]

    UBA1 -->|"activates"| Aging
    UBA1 -->|"activates"| Cancer
    UBA1 -->|"activates"| Inflammation
    UBA1 -->|"associated with"| Senescence
    UBA1 -->|"associated with"| AND
    UBA1 -->|"activates"| AGING
    INFLAMMATION -->|"activates"| UBA1
    UBA1 -->|"implicated in"| neurodegeneration

    style UBA1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (11)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Senescence	associated_with	disease	0.65
pyroptosis	participates_in	pathway	0.60
AGING	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
UBE2L3	activates	gene	0.60
stem cells	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
PARK2	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
ROS	activates	gene	0.60
NLRP3	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBA1 in their description or question text

No additional research found