Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UROCORTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
UROCORTIN encodes a neuroprotective peptide in the corticotropin-releasing hormone family, implicated in Parkinson's disease, Alzheimer's disease, and stress response pathways
| Gene Symbol | UCN |
| Aliases | UROCORTIN |
| Chromosome | 2p23.3 |
| Protein Family | CRF/Cortistatin/UCN |
| Function | encodes a 40-amino acid neuropeptide belonging to the corticotropin-releasing hormone (CRH) family. |
| Primary Expression | pituitary, cortex, and cerebellum |
| Molecular Weight | 4.7 kDa |
| Amino Acids | 40 aa |
| Pathways | Blood-Brain Barrier, Neuroprotection |
| UniProt ID | Q9UBB4 |
| Ensembl ID | ENSG00000163794 |
| GeneCards | UCN |
| Human Protein Atlas | UCN |
| Protein Name | Urocortin |
| Peptide Length | 40 amino acids |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Interactions | CRHR1, Leptin, CRH, AND |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
UROCORTIN["<b>UROCORTIN</b>"]
Ms{"Ms"}
UROCORTIN -->|"regulates"| Ms
CRH["CRH"]
UROCORTIN -->|"associated with"| CRH
CRHR1["CRHR1"]
UROCORTIN -->|"associated with"| CRHR1
AND["AND"]
UROCORTIN -->|"associated with"| AND
neurodegeneration["neurodegeneration"]
UROCORTIN -->|"implicated in"| neurodegeneration
CRH -->|"associated with"| UROCORTIN
CRHR1 -->|"associated with"| UROCORTIN
style UROCORTIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Anxiety | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| CRH | associated_with | gene | 0.60 |
| CRHR1 | associated_with | gene | 0.60 |
| Leptin | interacts_with | protein | 0.60 |
| CRH | interacts_with | gene | 0.60 |
| Blood-Brain Barrier | activates | pathway | 0.60 |
| Endothelial | activates | cell_type | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| AND | activates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| App | regulates | protein | 0.60 |
| Neuron | transports | cell_type | 0.60 |
| Endothelial Cell | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| CRHR1 | interacts_with | gene | 0.50 |
| ANXIETY | regulates | gene | 0.50 |
| Neuroprotection | regulates | process | 0.50 |
| NEURONS | expressed_in | concept | 0.50 |
| ENDOTHELIAL | activates | concept | 0.50 |
| ENDOTHELIAL CELLS | activates | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||