gene

CRHR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRHR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

157Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Corticotropin Releasing Hormone Receptor 1 - G protein-coupled receptor mediating stress response, implicated in depression, anxiety, and Alzheimer's disease

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🧬 Gene Info

Gene Symbol	CRHR1
Aliases	Corticotropin Releasing Hormone Receptor 1
Protein Type	Receptor
Function	The receptor consists of
Primary Expression	brain regions involved in stress, emotion, and memory regulation, including the cortex, hippocampus, amygdala, and pituitary gland
Amino Acids	444 aa
Pathways	Autophagy, Er Stress, Hpa Axis, Immune Response, MAPK signaling
Ensembl ID	ENSG00000120088
GeneCards	CRHR1
Human Protein Atlas	CRHR1
N-terminal extracellular domain	Contains the CRH-binding site
Seven transmembrane domains	Typical GPCR structure
C-terminal intracellular domain	Couples to G proteins and interacts with downstream effectors
HPA axis hyperactivity	Depressed patients often show elevated CRH levels and increased CRHR1 expression
Genetic associations	Polymorphisms in CRHR1 have been linked to MDD susceptibility and treatment response
Associated Diseases	Addiction, Alzheimer's disease, Depression, Dysbiosis, Hypersexual Disorder, Ms
Interactions	NR3C1, JUN, BDNF, IL18BP, CALCA, FKBP5
KG Connections	157 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    CRH["CRH"] -->|"activates"| CRHR1["CRHR1"]
    CRHR1["CRHR1"] -.->|"inhibits"| MITOCHONDRIA["MITOCHONDRIA"]
    CRHR1["CRHR1"] -->|"associated with"| Ms["Ms"]
    CRHR1["CRHR1"] -->|"associated with"| Depression["Depression"]
    CRHR1["CRHR1"] -->|"expressed in"| Tumor["Tumor"]
    CRHR1["CRHR1"] -->|"activates"| Als["Als"]
    CRHR1["CRHR1"] -.->|"inhibits"| Ms["Ms"]
    CRHR1["CRHR1"] -->|"activates"| Aging["Aging"]
    CRHR1["CRHR1"] -->|"activates"| Ms["Ms"]
    CRHR1["CRHR1"] -->|"regulates"| Ms["Ms"]
    CRHR1["CRHR1"] -->|"activates"| ALS["ALS"]
    CRHR1["CRHR1"] -->|"activates"| CAMP["CAMP"]
    style CRH fill:#006494,stroke:#333,color:#e0e0e0
    style CRHR1 fill:#006494,stroke:#333,color:#e0e0e0
    style MITOCHONDRIA fill:#006494,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style CAMP fill:#006494,stroke:#333,color:#e0e0e0

Outgoing (106)

Target	Relation	Type	Str
Hpa Axis	involved_in	pathway	0.90
Hypersexual Disorder	associated_with	disease	0.80
MITOCHONDRIA	inhibits	cell_type	0.72
Alzheimer's disease	associated_with	disease	0.70
Addiction	methylates	disease	0.65
Ptsd	inhibits	disease	0.65
Addiction	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Als	activates	disease	0.65
Ms	inhibits	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Ms	regulates	disease	0.65
ALS	activates	disease	0.65
Anxiety	inhibits	disease	0.65
Depression	methylates	disease	0.65
Depression	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
CAMP	activates	protein	0.64
PTSD	inhibits	entity	0.60
UROCORTIN	interacts_with	entity	0.60
NR3C1	interacts_with	gene	0.60
JUN	associated_with	gene	0.60
TNF	associated_with	gene	0.60
NR3C1	expressed_in	gene	0.60
JUN	activates	gene	0.60
ESR1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ESR2	expressed_in	gene	0.60
NR3C1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
IL18BP	inhibits	gene	0.60
CALCA	inhibits	gene	0.60
FKBP5	interacts_with	gene	0.60
CRH	interacts_with	gene	0.60
CRH	expressed_in	gene	0.60
IL18	inhibits	gene	0.60
FKBP5	inhibits	gene	0.60
RAMP1	inhibits	gene	0.60
CRH	inhibits	gene	0.60
CRH	activates	gene	0.60
CRH	associated_with	gene	0.60
POMC	expressed_in	gene	0.60
UROCORTIN	associated_with	gene	0.60
AVP	expressed_in	gene	0.60
P2RX7	inhibits	gene	0.60
JUN	methylates	gene	0.60
P62	inhibits	gene	0.60

Incoming (51)

Source	Relation	Type	Str
CRH	activates	protein	0.87
DNA Methylation	regulates	mechanism	0.85
CRH	interacts_with	protein	0.64
FKBP5	interacts_with	gene	0.60
CRH	expressed_in	gene	0.60
AVP	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
IL18	inhibits	gene	0.60
RAMP1	inhibits	gene	0.60
FKBP5	inhibits	gene	0.60
CRH	inhibits	gene	0.60
UROCORTIN	associated_with	gene	0.60
CRH	associated_with	gene	0.60
BDNF	inhibits	gene	0.60
CALCA	inhibits	gene	0.60
TNF	associated_with	gene	0.60
TNF	expressed_in	gene	0.60
ESR1	expressed_in	gene	0.60
JUN	activates	gene	0.60
ESR2	expressed_in	gene	0.60
NR3C1	expressed_in	gene	0.60
NR3C1	inhibits	gene	0.60
IL18BP	inhibits	gene	0.60
JUN	associated_with	gene	0.60
NR3C1	interacts_with	gene	0.60
P2RX7	inhibits	gene	0.60
KEAP1	inhibits	gene	0.60
RAS	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
DEPRESSION	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
DNA	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
GENES	inhibits	gene	0.60
IL12	expressed_in	gene	0.60
NR3C2	expressed_in	gene	0.60
AND	associated_with	gene	0.60
CRHBP	interacts_with	gene	0.60
TNF-ALPHA	associated_with	gene	0.60
IL-6	associated_with	gene	0.60
RNA	inhibits	gene	0.60
ANXIETY	inhibits	gene	0.60
HPA AXIS RELATED GENES	associated_with	gene	0.60
AND	expressed_in	gene	0.60
MAPK	activates	gene	0.60
TNF-ALPHA	methylates	gene	0.60
STROKE	inhibits	gene	0.60
ptsd	activates	disease	0.50
UROCORTIN	interacts_with	gene	0.50
CRH	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CRHR1

Understanding Entity Pages

Summary

Wiki Pages (21)

CRHR1

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Glucocorticoid Signaling Pathway in Neurodegeneration

cortisol-tau-pathway

Hypothalamic-Pituitary-Adrenal Axis

HPA Axis Neurons in Neurodegeneration

Bed Nucleus of Stria Terminalis in Stress

CRH-Positive Hippocampal Neurons

Paraventricular Hypothalamus Neurons

Stress Response in Neurodegeneration

Bed Nucleus of the Stria Terminalis Dorsal Neurons in Neurodegeneration

Periventricular Nucleus in Stress

Hypothalamic CRH Neurons

Paraventricular Nucleus Neuroendocrine Neurons

Central Nucleus Amygdala Neurons

Corticotropin Releasing Hormone (CRH)

Periventricular Nucleus Hypothalamus

Paraventricular Hypothalamic Neurons in Neurodegeneration

Amygdala CRH Neurons

CRF Receptor 1 Neurons

cAMP Signaling Pathway in Neurodegeneration

Pathway Diagram

Outgoing (106)

Incoming (51)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)