Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WWTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
WWTR1 is a protein involved in neurodegeneration research. Key relationships include: contributes to, implicated in, associated with. Associated with Als, Cardiac, Cardiovascular. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | WWTR1 |
| Full Name | WW Domain Containing Transcription Regulator 1 |
| Aliases | WW Domain Containing Transcription Regulator 1, Hippo Effector |
| Chromosome | 3q25.1 |
| Function | encodes a 400 amino acid transcriptional co-activator that functions as a central effector of the Hippo signaling pathway. |
| Primary Expression | neural progenitor cells, with high levels in the ventricular zone and subventricular zone |
| Molecular Weight | 42.8 kDa |
| Amino Acids | 400 aa |
| Exons | 7 |
| Ensembl ID | ENSG00000018408 |
| GeneCards | WWTR1 |
| Human Protein Atlas | WWTR1 |
| RUNX2/3 | Regulates osteogenic and chondrogenic differentiation |
| TBX5 | Cardiac development; mutations disrupting TAZ–TBX5 interaction cause congenital heart defects |
| SMAD2/3 | Integrates TGF-β signaling with Hippo pathway output |
| Associated Diseases | Als |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
WWTR1["<b>WWTR1</b>"]
Heart_Failure{"Heart Failure"}
WWTR1 -->|"contributes to"| Heart_Failure
Cardiovascular{"Cardiovascular"}
WWTR1 -->|"contributes to"| Cardiovascular
Als{"Als"}
WWTR1 -->|"associated with"| Als
Cardiac{"Cardiac"}
WWTR1 -->|"contributes to"| Cardiac
Ms{"Ms"}
WWTR1 -->|"contributes to"| Ms
Apoptosis(["Apoptosis"])
WWTR1 -->|"contributes to"| Apoptosis
neurodegeneration["neurodegeneration"]
WWTR1 -->|"implicated in"| neurodegeneration
HIPPO["HIPPO"]
HIPPO -->|"contributes to"| WWTR1
YAP1["YAP1"]
YAP1 -->|"contributes to"| WWTR1
LMNA["LMNA"]
LMNA -->|"contributes to"| WWTR1
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"contributes to"| WWTR1
NUCLEAR_INTEGRITY["NUCLEAR INTEGRITY"]
NUCLEAR_INTEGRITY -->|"contributes to"| WWTR1
style WWTR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | contributes_to | disease | 0.65 |
| Cardiovascular | contributes_to | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cardiac | contributes_to | disease | 0.65 |
| Ms | contributes_to | disease | 0.65 |
| Apoptosis | contributes_to | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| YAP1 | contributes_to | gene | 0.60 |
| LMNA | contributes_to | gene | 0.60 |
| HIPPO | contributes_to | gene | 0.60 |
| APOPTOSIS | contributes_to | gene | 0.60 |
| NUCLEAR INTEGRITY | contributes_to | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||