protein

WWTR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WWTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
0Analyses
6Outgoing
5Incoming

Summary

WWTR1 is a protein involved in neurodegeneration research. Key relationships include: contributes to, implicated in, associated with. Associated with Als, Cardiac, Cardiovascular. Connected to 12 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolWWTR1
Full NameWW Domain Containing Transcription Regulator 1
AliasesWW Domain Containing Transcription Regulator 1, Hippo Effector
Chromosome3q25.1
Functionencodes a 400 amino acid transcriptional co-activator that functions as a central effector of the Hippo signaling pathway.
Primary Expressionneural progenitor cells, with high levels in the ventricular zone and subventricular zone
Molecular Weight42.8 kDa
Amino Acids400 aa
Exons7
Ensembl IDENSG00000018408
GeneCardsWWTR1
Human Protein AtlasWWTR1
RUNX2/3Regulates osteogenic and chondrogenic differentiation
TBX5Cardiac development; mutations disrupting TAZ–TBX5 interaction cause congenital heart defects
SMAD2/3Integrates TGF-β signaling with Hippo pathway output
Associated DiseasesAls
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

WWTR1 (TAZ) — WW Domain Containing Transcription Regulator 1, Hippo Effector

gene · 1763 words

TAZ (WWTR1)

gene · 3051 words

YAP/TAZ Signaling Pathway in Neurodegeneration

mechanism · 2603 words

YAP/TAZ (Hippo) Signaling in Neurodegeneration

mechanism · 2101 words

LATS1 — Large Tumor Suppressor Kinase 1, Hippo Pathway

gene · 1653 words

Hippo Signaling in 4R-Tauopathies

mechanism · 1518 words

Pathway Diagram

graph TD
    WWTR1["<b>WWTR1</b>"]
    Heart_Failure{"Heart Failure"}
    WWTR1 -->|"contributes to"| Heart_Failure
    Cardiovascular{"Cardiovascular"}
    WWTR1 -->|"contributes to"| Cardiovascular
    Als{"Als"}
    WWTR1 -->|"associated with"| Als
    Cardiac{"Cardiac"}
    WWTR1 -->|"contributes to"| Cardiac
    Ms{"Ms"}
    WWTR1 -->|"contributes to"| Ms
    Apoptosis(["Apoptosis"])
    WWTR1 -->|"contributes to"| Apoptosis
    neurodegeneration["neurodegeneration"]
    WWTR1 -->|"implicated in"| neurodegeneration
    HIPPO["HIPPO"]
    HIPPO -->|"contributes to"| WWTR1
    YAP1["YAP1"]
    YAP1 -->|"contributes to"| WWTR1
    LMNA["LMNA"]
    LMNA -->|"contributes to"| WWTR1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"contributes to"| WWTR1
    NUCLEAR_INTEGRITY["NUCLEAR INTEGRITY"]
    NUCLEAR_INTEGRITY -->|"contributes to"| WWTR1
    style WWTR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

TargetRelationTypeStr
Heart Failurecontributes_todisease0.65
Cardiovascularcontributes_todisease0.65
Alsassociated_withdisease0.65
Cardiaccontributes_todisease0.65
Mscontributes_todisease0.65

Incoming (5)

SourceRelationTypeStr
YAP1contributes_togene0.60
LMNAcontributes_togene0.60
HIPPOcontributes_togene0.60
APOPTOSIScontributes_togene0.60
NUCLEAR INTEGRITYcontributes_togene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found