concept

HIPPO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIPPO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

658Connections

20Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

HIPPO is a concept in neurodegeneration research. Key relationships include: regulates, activates, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 425 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HIPPO
Key Genes/Proteins	YAP, CANCER, AKT
Related Diseases	Als, Tumor, Cancer
Related Pathways	Hippo Pathway, Apoptosis
Linked Hypotheses	29 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HIPPO["HIPPO"]
    HIPPO -->|"interacts"| FoxO1["FoxO1"]
    HIPPO -->|"regulates"| TNF_["TNFalpha"]
    HIPPO -->|"regulates"| IL_6["IL-6"]
    HIPPO -->|"regulates"| Carcinoma["Carcinoma"]
    HIPPO -->|"regulates"| Als["Als"]
    HIPPO -->|"target for"| Ms["Ms"]
    HIPPO -->|"target for"| Inflammation["Inflammation"]
    HIPPO -->|"activates"| Cancer["Cancer"]
    HIPPO -->|"target for"| Tumor["Tumor"]
    CDH1["CDH1"] -->|"regulates"| HIPPO
    MPXV["MPXV"] -->|"regulates"| HIPPO
    MTOR["MTOR"] -->|"regulates"| HIPPO
    AGING["AGING"] -->|"inhibits"| HIPPO
    GAL["GAL"] -->|"regulates"| HIPPO
    FOS["FOS"] -->|"contributes to"| HIPPO
    MT_ATP6["MT-ATP6"] -->|"regulates"| HIPPO
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| HIPPO
    PI3K["PI3K"] -->|"regulates"| HIPPO

Outgoing (427)

Target	Relation	Type	Str
Als	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	1.00
Cancer	regulates	disease	1.00
Cancer	therapeutic_target	disease	1.00
YAP	activates	gene	1.00
Hippo Pathway	regulates	pathway	1.00
Apoptosis	regulates	pathway	0.90
Als	regulates	disease	0.85
Cancer	activates	disease	0.85
Tumor	regulates	disease	0.85
CANCER	activates	gene	0.80
AKT	activates	gene	0.80
Apoptosis	activates	pathway	0.80
YAP	regulates	gene	0.80
YAP	associated_with	gene	0.80
MYC	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
Differentiation	therapeutic_target	pathway	0.80
Carcinoma	regulates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Tumor	activates	disease	0.75
Als	associated_with	disease	0.75
STAT3	associated_with	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
Mtor	regulates	pathway	0.70
Epigenetic	therapeutic_target	pathway	0.70
Hedgehog	regulates	pathway	0.70
CANCER	regulates	gene	0.70
Autophagy	activates	pathway	0.70
Oxidative Stress	regulates	pathway	0.70
Ferroptosis	regulates	pathway	0.70
Wnt	associated_with	pathway	0.70
Tgf-Β	associated_with	pathway	0.70
EGF	activates	gene	0.70
YAP1	activates	gene	0.70
FERROPTOSIS	regulates	gene	0.70
Metastasis	therapeutic_target	pathway	0.70
Angiogenesis	therapeutic_target	pathway	0.70
Hippo Pathway	associated_with	pathway	0.70
Hippo Pathway	therapeutic_target	pathway	0.70
GENES	regulates	gene	0.70
Autophagy	regulates	pathway	0.70
AKT	therapeutic_target	gene	0.70
Ms	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Senescence	regulates	disease	0.65
Aging	inhibits	disease	0.65
Ms	regulates	disease	0.65

Incoming (231)

Source	Relation	Type	Str
CANCER	regulates	gene	0.80
APOPTOSIS	regulates	gene	0.80
PI3K	activates	gene	0.70
TAZ	regulates	gene	0.70
EGFR	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
APOPTOSIS	activates	gene	0.70
MST1	regulates	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
PI3K	therapeutic_target	gene	0.70
PI3K	associated_with	gene	0.70
MPXV	regulates	disease	0.64
MTOR	regulates	gene	0.60
AGING	inhibits	gene	0.60
GAL	regulates	gene	0.60
AGING	contributes_to	gene	0.60
FOS	contributes_to	gene	0.60
MT-ATP6	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
PI3K	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
KRAS	activates	gene	0.60
BIP	activates	gene	0.60
ALS	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
YAP	regulates	gene	0.60
AQP4	activates	gene	0.60
GATA3	activates	gene	0.60
GATA2	activates	gene	0.60
ERK	inhibits	gene	0.60
SRC	inhibits	gene	0.60
MIRNAS	activates	gene	0.60
KCNMA1	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
PIEZO1	associated_with	gene	0.60
CANCER	activates	gene	0.60
LIF	activates	gene	0.60
CYTOKINES	activates	gene	0.60
MTOR	phosphorylates	gene	0.60
DSDNA	phosphorylates	gene	0.60
GAIN	phosphorylates	gene	0.60
KCNK2	associated_with	gene	0.60
TCR	associated_with	gene	0.60
AXON	activates	gene	0.60
CFTR	associated_with	gene	0.60
TRPV4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
GENES	activates	gene	0.60

Targeting Hypotheses (20)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.695	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy	0.681	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.677	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop transcranial alternating current stimulation to	0.639	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam	0.577	neurodegeneration	RNA binding protein dysregulation across
Optogenetic restoration of hippocampal gamma oscillations vi	0.566	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.554	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.538	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.508	Alzheimer's disease	Circuit-level neural dynamics in neurode
Dopaminergic Ventral Tegmental-Hippocampal Circuit Protectio	0.494	neuroscience	Circuit-level neural dynamics in neurode
Cholinergic Basal Forebrain-Hippocampal Circuit Protection	0.493	neuroscience	Circuit-level neural dynamics in neurode
Locus Coeruleus-Hippocampal Circuit Protection	0.480	neuroscience	Circuit-level neural dynamics in neurode
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu	0.470	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Zhi-Gan Formula improved insomnia and anxiety comorbidity in a mouse model via P [PMID:41525914]	Liu R, Wu Z, Yin Y, Song C, Zhang C et a	J Ethnopharmacol	2026	0
Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like e [PMID:41539634]	Yoon S, Chun E, Iqbal H, Kim SH, Kim SY	J Ethnopharmacol	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026	0
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026	0
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026	0
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026	0
Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsatur [PMID:41937329]	Akanchise T, Luo F, Angelov B, Deng Y, A	Adv Healthc Mater	2026	0
Single transient exposure to low-frequency low-intensity electrical stimulation [PMID:41942002]	Marcotto GS, Borghetti M, Bitraj J, Cava	Neuropharmacology	2026	0
Serpina1e mediates the exercise-induced enhancement of hippocampal memory in mal [PMID:41957371]	Kim H, Shin S, Han J, Yun K, Kim JS et a	Nat Commun	2026	0

HIPPO

Understanding Entity Pages

Summary

Wiki Pages (21)

payload-hippo-pathway-modulation-cbs

Corticobasal Syndrome (CBS)

Novel Therapy Index

Transcriptional Regulation in Neurodegeneration

KRIT1 — Krev Interaction Trapped 1 (CCM1)

Paraneoplastic Cerebellar Degeneration Neurons

Pathway Diagram

Outgoing (427)

Incoming (231)

Targeting Hypotheses (20)

Mentioning Analyses (5)

What are the specific circulating factors in exercise-conditioned plasma that me

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

Human connectome alterations and network-level dysfunction in Alzheimer disease

Circuit-level neural dynamics in neurodegeneration

Circuit-level neural dynamics in neurodegeneration

Related Papers (20)

HIPPO

Understanding Entity Pages

Summary

Wiki Pages (21)

payload-hippo-pathway-modulation-cbs

Corticobasal Syndrome (CBS)

Novel Therapy Index

Transcriptional Regulation in Neurodegeneration

KRIT1 — Krev Interaction Trapped 1 (CCM1)

Paraneoplastic Cerebellar Degeneration Neurons

TEAD1 — TEA Domain Transcription Factor 1

TAZ (WWTR1)

PDCD10 Gene (Programmed Cell Death 10)

PP2A Protein

DVL3 — Dishevelled Segment Polarity Protein 3

RAN Gene

wnt-beta-catenin-signaling-pathway

YAP/TAZ Signaling Pathway in Neurodegeneration

SCRIB Gene

Disease Progression Staging Synthesis

YAP/TAZ (Hippo) Signaling in Neurodegeneration

SLIT2 — Slit Guidance Ligand 2

PPM1A Protein

MITF Gene — Microphthalmia-Associated Transcription Factor

CCM2 Protein

Pathway Diagram

Outgoing (427)

Incoming (231)

Targeting Hypotheses (20)

Mentioning Analyses (5)

What are the specific circulating factors in exercise-conditioned plasma that me

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

Human connectome alterations and network-level dysfunction in Alzheimer disease

Circuit-level neural dynamics in neurodegeneration

Circuit-level neural dynamics in neurodegeneration

Related Papers (20)