Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WNT SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | WNT SIGNALING PATHWAY |
Knowledge base pages for this entity
graph TD
WNT_SIGNALING_PATHWAY["WNT SIGNALING PATHWAY"]
WNT_SIGNALING_PATHWAY -->|"activates"| HIF_1_["HIF-1alpha"]
WNT_SIGNALING_PATHWAY -->|"regulates"| MYC["MYC"]
WNT_SIGNALING_PATHWAY -->|"contributes to"| High_Risk_Ovarian_Cancer["High-Risk Ovarian Cancer"]
WNT_SIGNALING_PATHWAY -->|"regulates"| Ischemia_reperfusion_injury["Ischemia-reperfusion injury"]
WNT_SIGNALING_PATHWAY -->|"regulates"| tissue_damage["tissue damage"]
WIF1["WIF1"] -->|"inhibits"| WNT_SIGNALING_PATHWAY
NPC1["NPC1"] -->|"regulates"| WNT_SIGNALING_PATHWAY
Cluster_1_Upregulated_Genes["Cluster 1 Upregulated Genes"] -->|"involved_in"| WNT_SIGNALING_PATHWAY
Cluster_1_Upregulated_DEGs["Cluster 1 Upregulated DEGs"] -->|"upregulates"| WNT_SIGNALING_PATHWAY
EPHA5["EPHA5"] -->|"activates"| WNT_SIGNALING_PATHWAY
BAX["BAX"] -->|"regulates"| WNT_SIGNALING_PATHWAY
BCL2["BCL2"] -->|"regulates"| WNT_SIGNALING_PATHWAY
DKK1["DKK1"] -->|"inhibits"| WNT_SIGNALING_PATHWAY| Target | Relation | Type | Str |
|---|---|---|---|
| HIF-1α | activates | protein | 0.90 |
| AUTOPHAGY | regulates | process | 0.90 |
| MYC | regulates | gene | 0.85 |
| Ovarian Cancer | contributes_to | disease | 0.85 |
| High-Risk Ovarian Cancer | contributes_to | phenotype | 0.78 |
| Ischemia-reperfusion injury | regulates | process | 0.70 |
| tissue damage | regulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| WIF1 | inhibits | protein | 0.95 |
| Thermal Adaptation | inhibits | process | 0.95 |
| NPC1 | regulates | gene | 0.90 |
| Cluster 1 Upregulated Genes | involved_in | biomarker | 0.88 |
| Cluster 1 Upregulated DEGs | upregulates | biomarker | 0.85 |
| EPHA5 | activates | gene | 0.80 |
| BAX | regulates | gene | 0.80 |
| OPTN | associated_with | gene | 0.75 |
| mechanosensitive ion channel | regulates | protein | 0.75 |
| BCL2 | regulates | gene | 0.70 |
| DKK1 | inhibits | protein | 0.70 |
| Notch pathway | interacts_with | pathway | 0.70 |
| phosphatidylinositol 3-kinase/protein kinase B pathway | interacts_with | pathway | 0.70 |
| transforming growth factor-β pathway | interacts_with | pathway | 0.70 |
| bone morphogenetic protein pathway | interacts_with | pathway | 0.70 |
| LRP1 | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||