protein

XRCC3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XRCC3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

10Outgoing

6Incoming

0Experiments

0Debates

Summary

XRCC3 is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, implicated in. Associated with Als, Cancer, Prostate Cancer. Connected to 17 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	XRCC3
Full Name	X-Ray Repair Cross Complementing 3
Chromosome	14q32.33
Function	XRCC3 functions primarily in the homologous recombination pathway of DNA double-strand break (DSB) repair:
Subcellular Localization	## Protein Structure
Molecular Weight	38 kDa
Pathways	Apoptosis, Invasion
UniProt ID	[Q9UQE5](https://www.uniprot.org/uniprot/Q9UQE5)
Ensembl ID	ENSG00000113147
OMIM	600675
GeneCards	XRCC3
Human Protein Atlas	XRCC3
Associated Diseases	Tumor
Interactions	APOPTOSIS, BAX, CANCER, DNA, P53
KG Connections	16 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

XRCC3

gene · 946 words

→

XRCC3 Protein

protein · 633 words

→

Pathway Diagram

graph TD
    XRCC3["XRCC3"]
    Cancer{"Cancer"}
    XRCC3 -->|"activates"| Cancer
    Als{"Als"}
    XRCC3 -->|"activates"| Als
    Tumor{"Tumor"}
    XRCC3 -->|"associated with"| Tumor
    BAX["BAX"]
    XRCC3 -->|"activates"| BAX
    GENES["GENES"]
    XRCC3 -->|"expressed in"| GENES
    DNA["DNA"]
    XRCC3 -->|"activates"| DNA
    P53["P53"]
    XRCC3 -->|"activates"| P53
    Apoptosis(["Apoptosis"])
    XRCC3 -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    XRCC3 -->|"implicated in"| neurodegeneration
    style XRCC3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Tumor	associated_with	disease	0.65
Cancer	activates	disease	0.65
Prostate Cancer	activates	disease	0.65
Als	activates	disease	0.65
Apoptosis	activates	pathway	0.60
BAX	activates	gene	0.60
Invasion	activates	pathway	0.60
GENES	expressed_in	gene	0.60
DNA	activates	gene	0.60
P53	activates	gene	0.60

Incoming (6)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	0.60
P53	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	expressed_in	gene	0.60
DNA	activates	gene	0.60
BAX	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XRCC3 in their description or question text

No additional research found