Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BETA-CATENIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | BETA |
| Full Name | CATENIN |
| Protein Family | Beta-catenin family, Armadillo repeat proteins |
| Function | of 781 amino acids that is expressed in virtually all tissues, with particularly high expression in the brain |
| Subcellular Localization | Cytoplasm, nucleus, cell junctions |
| Molecular Weight | 85 kDa |
| Amino Acids | 781 aa |
| Pathways | Wnt signaling, Wnt |
| UniProt ID | P35222 |
| GeneCards | BETA |
| Human Protein Atlas | BETA |
| Gene | CTNNB1 |
| PDB | 1JDH, 3BCT |
| Mol. Weight | 85 kDa |
| Interactions | MTCL1, UBIQUITIN, CAV3, LEF1, CAV3.1, CACNA1G |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BETA_CATENIN["<b>BETA-CATENIN</b>"]
CARCINOMA{"CARCINOMA"}
BETA_CATENIN -->|"activates"| CARCINOMA
NEURONS["NEURONS"]
BETA_CATENIN -->|"interacts_with"| NEURONS
Genes["Genes"]
BETA_CATENIN -->|"activates"| Genes
Differentiation["Differentiation"]
BETA_CATENIN -->|"activates"| Differentiation
MTCL1(["MTCL1"])
MTCL1 -->|"activates"| BETA_CATENIN
UBIQUITIN(["UBIQUITIN"])
UBIQUITIN -->|"activates"| BETA_CATENIN
CAV3(["CAV3"])
CAV3 -->|"interacts_with"| BETA_CATENIN
LEF1(["LEF1"])
LEF1 -->|"interacts_with"| BETA_CATENIN
style BETA_CATENIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's disease | downregulates | disease | 0.80 |
| MELANOMA | downregulates | disease | 0.80 |
| CARCINOMA | activates | disease | 0.50 |
| NEURONS | interacts_with | concept | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| THALAMUS | associated_with | concept | 0.50 |
| THALAMUS | interacts_with | concept | 0.50 |
| NEURONS | activates | concept | 0.50 |
| THALAMUS | activates | concept | 0.50 |
| Hippocampus | activates | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C1QBP | activates | protein | 0.80 |
| MTCL1 | activates | gene | 0.50 |
| UBIQUITIN | activates | protein | 0.50 |
| CAV3 | interacts_with | gene | 0.50 |
| LEF1 | interacts_with | gene | 0.50 |
| CAV3.1 | interacts_with | protein | 0.50 |
| CACNA1G | interacts_with | protein | 0.50 |
| LEF1 | activates | gene | 0.50 |
| LEF1 | associated_with | gene | 0.50 |
| WNT3A | activates | gene | 0.50 |
| CACNA1G | activates | protein | 0.50 |
| PRESENILIN | regulates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||