gene

CAV3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAV3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

70Connections

0Hypotheses

0Analyses

50Outgoing

14Incoming

Summary

Caveolin 3 - muscle-specific caveolin essential for skeletal muscle function and neuromuscular junctions

View on Wiki →

🧬 Gene Info

Gene Symbol	CAV3
Aliases	Caveolin 3
Function	Cav3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Primary Expression	Thalamus, Hippocampus
Molecular Weight	18 kDa
Pathways	Amyloid, Complement, Wnt
GeneCards	CAV3
Human Protein Atlas	CAV3
Dystrophin	Direct binding
β-Dystroglycan	Direct binding
nNOS	Scaffold
Integrins	Coordinate
G proteins	Scaffold
Mutation Type	Effect
Nonsense	Truncated protein
Associated Diseases	Ataxia, Autism, Epilepsy, Spinocerebellar Ataxia
Interactions	WNT3A, CACNA1G, GAIN, LEF1, Rb, AMYLOID
KG Connections	70 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CAV3["<b>CAV3</b>"]
    ALS{"ALS"}
    CAV3 -->|"inhibits"| ALS
    Alzheimer{"Alzheimer"}
    CAV3 -->|"inhibits"| Alzheimer
    Aging{"Aging"}
    CAV3 -->|"inhibits"| Aging
    AMYLOID["AMYLOID"]
    CAV3 -->|"inhibits"| AMYLOID
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    CAV3 -->|"inhibits"| ALZHEIMER_S_DISEASE
    ALZHEIMER["ALZHEIMER"]
    CAV3 -->|"inhibits"| ALZHEIMER
    AGING["AGING"]
    CAV3 -->|"inhibits"| AGING
    Amyloid(["Amyloid"])
    CAV3 -->|"inhibits"| Amyloid
    Complement(["Complement"])
    CAV3 -->|"inhibits"| Complement
    AND["AND"]
    CAV3 -->|"inhibits"| AND
    neurodegeneration["neurodegeneration"]
    CAV3 -->|"implicated in"| neurodegeneration
    ALZHEIMER_S_DISEASE -->|"inhibits"| CAV3
    ALZHEIMER -->|"inhibits"| CAV3
    style CAV3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

Target	Relation	Type	Str
ALS	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Als	inhibits	disease	0.65
Autism	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
GAIN	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
LEF1	regulates	gene	0.60
WNT3A	activates	gene	0.60
Purkinje	associated_with	cell_type	0.60
Rb	inhibits	protein	0.60
Rb	activates	protein	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AGING	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
Complement	inhibits	pathway	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
Wnt	activates	pathway	0.60
Neuron	activates	cell_type	0.60
EPILEPSY	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
AND	associated_with	gene	0.60
Amyloid Beta	inhibits	protein	0.60
Ras	activates	protein	0.60
Ras	associated_with	protein	0.60
Thalamus	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
CACNA1G	interacts_with	protein	0.50
GAIN	activates	gene	0.50
LEF1	interacts_with	gene	0.50
CAV3.1	inhibits	protein	0.50
AMYLOID BETA	inhibits	concept	0.50
Alzheimer'S Disease	inhibits	disease	0.50
disease	inhibits	disease	0.50
ALZHEIMER'S	inhibits	concept	0.50
CAV3.1	expressed_in	protein	0.50
ALZHEIMER	expressed_in	gene	0.50
aging	expressed_in	phenotype	0.50
Alzheimer'S Disease	expressed_in	disease	0.50
AMYLOID	expressed_in	gene	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
CAV3.1	associated_with	protein	0.50

Incoming (14)

Source	Relation	Type	Str
CACNA1G	encodes	gene	0.60
CACNA1G	associated_with	gene	0.60
GAIN	associated_with	gene	0.60
LEF1	regulates	gene	0.60
TRPC3	activates	gene	0.60
CAV1	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AGING	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
AND	associated_with	gene	0.60
GENES	activates	gene	0.60
EPILEPSY	associated_with	gene	0.60
RNA	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CAV3

Understanding Entity Pages

Summary

Wiki Pages (21)

CAV3

calcium-dysregulation-comparison

Calcium Signaling Dysregulation in Neurodegeneration

ventral-anterior-thalamic-nucleus

Calcium Signaling Dysregulation in Alzheimer's Disease

Calcium Signaling Pathway in Neurodegeneration

Ion Channel Dysfunction in Frontotemporal Dementia

ion-channel-dysfunction-disease-comparison

calcium-dysregulation-alzheimers

Calcium Homeostasis in Neurodegeneration

Neurons

CAV1

Calcium Signaling Dysregulation in Alzheimer's Disease

Calcium Homeostasis Dysfunction in CBS/PSP

Cav1.3 Calcium Channel Modulators for Parkinson's Disease

Spinothalamic Neurons

Chief Sensory Trigeminal Nucleus

Calcium Dysregulation in 4R-Tauopathies — Cross-Disease Comparison

Posterior Thalamic Nuclear Group Sensory Neurons

Primidone

Spinal Dorsal Horn Lamina I Projection Neurons

Pathway Diagram

Outgoing (56)

Incoming (14)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)