gene

LEF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LEF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

166Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

LEF1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, expressed in, associated with. Associated with Als, Cancer, Carcinoma. Connected to 102 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LEF1
Chromosome	4q25
Protein Type	Transcription Factor
Function	is a transcription factor belonging to the T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) family of DNA-binding proteins.
Primary Expression	multiple regions of the developing and adult brain, with particularly high expression in the hippocampal formation, cerebral [cortex](/brain-regions/c
Amino Acids	399 aa
Pathways	Wnt, Wnt pathway, Wnt signaling
GeneCards	LEF1
Human Protein Atlas	LEF1
Gene Category	Examples
Proliferation	c-Myc, Cyclin D1
Stemness	Sox2, Oct4
Neurogenesis	NeuroD1, Ascl1
Synaptic	PSD-95, Synapsin
Survival	Bcl-2, survivin
Associated Diseases	neurodegeneration
Interactions	WNT3A, CACNA1G, SRPK1, TCF4, APOPTOSIS, AND
KG Connections	166 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LEF1["LEF1"]
    LEF1 -->|"expressed in"| Cancer["Cancer"]
    LEF1 -->|"expressed in"| Ms["Ms"]
    LEF1 -->|"target for"| Fibrosis["Fibrosis"]
    LEF1 -->|"target for"| Hepatitis["Hepatitis"]
    LEF1 -->|"target for"| Carcinoma["Carcinoma"]
    LEF1 -->|"target for"| Als["Als"]
    LEF1 -->|"target for"| Inflammation["Inflammation"]
    RB1["RB1"] -->|"expressed in"| LEF1
    FGF20["FGF20"] -->|"target for"| LEF1
    BRG1["BRG1"] -->|"target for"| LEF1
    NRCAM["NRCAM"] -->|"target for"| LEF1
    NOTCH2["NOTCH2"] -->|"target for"| LEF1
    EP300["EP300"] -->|"target for"| LEF1
    CTNNB1["CTNNB1"] -->|"target for"| LEF1
    NEUROD1["NEUROD1"] -->|"target for"| LEF1
    MYC["MYC"] -->|"target for"| LEF1
    VEGFA["VEGFA"] -->|"target for"| LEF1

Outgoing (108)

Target	Relation	Type	Str
Cancer	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	expressed_in	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
DVL1	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
CD44	therapeutic_target	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
RB1	expressed_in	gene	0.60
ABCB1	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60

Incoming (58)

Source	Relation	Type	Str
RB1	expressed_in	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
DVL1	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
SLC22A4	associated_with	gene	0.60
SLC22A5	associated_with	gene	0.60
PDGFRB	associated_with	gene	0.60
CREBBP	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
CAV3	regulates	gene	0.60
CACNA1G	activates	gene	0.60
CACNA1G	expressed_in	gene	0.60
EGFR	activates	gene	0.60
DVL1	interacts_with	gene	0.60
DVL1	co_expressed_with	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
CD44	targets	gene	0.60
CLDN1	targets	gene	0.60
DKK1	targets	gene	0.60
FGF18	targets	gene	0.60
FGF20	targets	gene	0.60
FZD7	targets	gene	0.60
IL10	targets	gene	0.60
JAG1	targets	gene	0.60
CTNNB1	activates	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
CDH1	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LEF1

Understanding Entity Pages

Summary

Wiki Pages (13)

LEF1

Wnt-Beta-Catenin Signaling Dysfunction Hypothesis in Parkinson's Disease

PITX3 Protein

FZD8 Gene

wnt-beta-catenin-signaling-pathway

slc22a5

CHD8 Gene

beta-catenin-protein

CTNNBIP1 Gene — Catenin Beta Interacting Protein 1 (ICAT)

DVL1 Gene

ppard

Dishevelled 1 Protein

Genes

Pathway Diagram

Outgoing (108)

Incoming (58)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)