Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CEREBRAL ISCHEMIA/REPERFUSION INJURY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CEREBRAL ISCHEMIA/REPERFUSION INJURY |
Knowledge base pages for this entity
graph TD
CEREBRAL_ISCHEMIA_REPERFUSION_["CEREBRAL ISCHEMIA/REPERFUSION INJURY"]
CEREBRAL_ISCHEMIA_REPERFUSION_ -->|"activates"| Piezo1["Piezo1"]
Yiqi_Tongluo_Granule["Yiqi Tongluo Granule"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
calycosin["calycosin"] -->|"treats"| CEREBRAL_ISCHEMIA_REPERFUSION_
Quercetin["Quercetin"] -->|"treats"| CEREBRAL_ISCHEMIA_REPERFUSION_
Calycosin["Calycosin"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
Microglia_Macrophages_M2_Polar["Microglia/Macrophages M2 Polarization"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
Myriocin["Myriocin"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
PI3K_Akt_Signaling_Pathway["PI3K-Akt Signaling Pathway"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
sulforaphane["sulforaphane"] -->|"treats"| CEREBRAL_ISCHEMIA_REPERFUSION_| Target | Relation | Type | Str |
|---|---|---|---|
| Piezo1 | activates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Yiqi Tongluo Granule | protects_against | drug | 0.95 |
| Inflammation | contributes_to | process | 0.95 |
| Ferroptosis | contributes_to | process | 0.95 |
| calycosin | treats | drug | 0.90 |
| Quercetin | treats | compound | 0.90 |
| Calycosin | protects_against | compound | 0.90 |
| Ceramide | associated_with | compound | 0.90 |
| LCN2 | contributes_to | protein | 0.90 |
| Microglia/Macrophages M2 Polarization | protects_against | phenotype | 0.85 |
| Myriocin | protects_against | drug | 0.85 |
| PI3K-Akt Signaling Pathway | protects_against | pathway | 0.80 |
| FBXO3 | associated_with | gene | 0.80 |
| YQTL | protects_against | compound | 0.80 |
| sulforaphane | treats | drug | 0.70 |
| PINK1 | protects_against | protein | 0.70 |
| Ligustilide | treats | drug | 0.70 |
| THSG | treats | drug | 0.70 |
| DZSM | protects_against | drug | 0.70 |
| mitophagy | protects_against | process | 0.70 |
| mitochondrial dysfunction | causes | process | 0.70 |
| mitochondrial dysfunction | associated_with | process | 0.70 |
| ITGAM | protects_against | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||