protein

ITGAM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITGAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

203Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ITGAM is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Als, Cancer, Cardiac. Connected to 31 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ITGAM
Protein Type	Receptor
Function	is a multifunctional immune receptor that binds complement fragment iC3b, ICAM-family ligands, fibrinogen, and damage-associated molecular patterns.
Amino Acids	1153 aa
Pathways	Complement
Ensembl ID	ENSG00000169896
GeneCards	ITGAM
Human Protein Atlas	ITGAM
Associated Diseases	Aging, Als, Alzheimer, Parkinson's disease, Senescence
Interactions	AIF1, AND, APOPTOSIS, C1QA, C1QB, C1QC
SciDEX Hypotheses	ITGAM/CD11b direct binding explains microglial pha
KG Connections	203 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ITGAM Gene

gene · 1750 words

→

ITGAM Protein

protein · 650 words

→

Pathway Diagram

graph TD
    ITGAM["ITGAM"]
    Ms{"Ms"}
    ITGAM -->|"activates"| Ms
    Cancer{"Cancer"}
    ITGAM -->|"activates"| Cancer
    Tumor{"Tumor"}
    ITGAM -->|"activates"| Tumor
    TNF["TNF"]
    ITGAM -->|"activates"| TNF
    NF__B["NF-KappaB"]
    ITGAM -->|"activates"| NF__B
    CXCL2["CXCL2"]
    ITGAM -->|"activates"| CXCL2
    CD14["CD14"]
    ITGAM -->|"activates"| CD14
    CANCER["CANCER"]
    ITGAM -->|"activates"| CANCER
    PPARG["PPARG"]
    ITGAM -->|"activates"| PPARG
    TNF__["TNF-Alpha"]
    ITGAM -->|"activates"| TNF__
    MSR1["MSR1"]
    ITGAM -->|"activates"| MSR1
    JUN["JUN"]
    ITGAM -->|"activates"| JUN
    ICAM1["ICAM1"]
    ICAM1 -->|"activates"| ITGAM
    TREM2["TREM2"]
    TREM2 -->|"activates"| ITGAM
    TLR2["TLR2"]
    TLR2 -->|"activates"| ITGAM
    NFKBIA["NFKBIA"]
    NFKBIA -->|"activates"| ITGAM
    MRC1["MRC1"]
    MRC1 -->|"activates"| ITGAM
    IL1B["IL1B"]
    IL1B -->|"activates"| ITGAM
    P53["P53"]
    P53 -->|"activates"| ITGAM
    style ITGAM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (129)

Target	Relation	Type	Str
synaptic engulfment	mediates	process	0.70
ALS	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Als	regulates	disease	0.65
Ischemia	activates	disease	0.65
Myocardial Infarction	activates	disease	0.65
Cardiac	activates	disease	0.65
Inflammation	activates	disease	0.65
ALS	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	regulates	disease	0.65
Senescence	associated_with	disease	0.65
MERTK	regulates	gene	0.60
C1QB	regulates	gene	0.60
C1S	regulates	gene	0.60
C1QB	biomarker_for	gene	0.60
AGING	associated_with	gene	0.60
Microglia	regulates	cell_type	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
Complement	regulates	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
locus coeruleus noradrenergic neurodegeneration	involved_in	disease_process	0.60
therapeutic_target_cerebral_IR_injury	therapeutic_target	therapeutic_target	0.60
C1R	regulates	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
cerebral ischemia/reperfusion injury	protects_against	disease_process	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
INOS	biomarker_for	gene	0.60
GENES	associated_with	gene	0.60
CD47	regulates	gene	0.60
C1QA	biomarker_for	gene	0.60
microglia polarization	regulates	process	0.60
immune regulation	involved_in	process	0.60
nerve injury repair	involved_in	process	0.60
microglial activation	regulates	process	0.60
Oxidative Stress	biomarker_for	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
Microglia	biomarker_for	cell_type	0.60
C1QA	regulates	gene	0.60
Neuron	associated_with	cell_type	0.60
Mitophagy	expressed_in	pathway	0.60

Incoming (74)

Source	Relation	Type	Str
AIF1	co_discussed	gene	0.60
GENES	activates	gene	0.60
CCL2	regulates	gene	0.60
C1QA	biomarker_for	gene	0.60
YWHAZ	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
CAV1	expressed_in	gene	0.60
CCND1	expressed_in	gene	0.60
TREM2	activates	gene	0.60
TLR2	activates	gene	0.60
NFKBIA	activates	gene	0.60
MRC1	activates	gene	0.60
IL1B	activates	gene	0.60
CD14	activates	gene	0.60
TNF	activates	gene	0.60
ANXA5	expressed_in	gene	0.60
ICAM1	activates	gene	0.60
C3	regulates	gene	0.60
P53	activates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
AGING	associated_with	gene	0.60
GENES	regulates	gene	0.60
SYNAPTIC PRUNING	associated_with	gene	0.60
COMPLEMENT GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
INOS	biomarker_for	gene	0.60
MERTK	regulates	gene	0.60
C1QB	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
AIF1	biomarker_for	gene	0.60
TYROBP	associated_with	gene	0.60
TREM2	biomarker_for	gene	0.60
CD68	biomarker_for	gene	0.60
CYBB	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C4B	biomarker_for	gene	0.60
VDAC1	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
RELA	expressed_in	gene	0.60
SIRPA	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
CD47	regulates	gene	0.60
C1R	biomarker_for	gene	0.60
C1S	biomarker_for	gene	0.60
C3	biomarker_for	gene	0.60
CHI3L1	biomarker_for	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ITGAM/CD11b direct binding explains microglial phagocytosis	0.582	molecular-biology	Does Alectinib truly bind C1q directly w

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does C1q function differ based on subcellular localization or binding partner id

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.750

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Does C1q function differ based on subcellular localization or binding partner id

closed · Rounds: 4 · Score: 0.68 · 2026-04-25

Related Research

Hypotheses and analyses mentioning ITGAM in their description or question text

No additional research found