Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CIRCADIAN CLOCK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CIRCADIAN CLOCK |
| Linked Hypotheses | 4 hypotheses |
Knowledge base pages for this entity
graph TD
CIRCADIAN_CLOCK["CIRCADIAN CLOCK"]
CIRCADIAN_CLOCK -->|"modulates"| Gene_Expression["Gene Expression"]
CIRCADIAN_CLOCK -->|"modulates"| Cell_Division["Cell Division"]
CIRCADIAN_CLOCK -->|"modulates"| DNA_Repair["DNA Repair"]
CIRCADIAN_CLOCK -->|"regulates"| Sleep_Wake_Cycles["Sleep/Wake Cycles"]
CIRCADIAN_CLOCK -->|"regulates"| Inflammation["Inflammation"]
CIRCADIAN_CLOCK -->|"regulates"| Neurodegeneration["Neurodegeneration"]
CIRCADIAN_CLOCK -->|"regulates"| Hormone_Release["Hormone Release"]
CIRCADIAN_CLOCK -->|"regulates"| Immune_Response["Immune Response"]
CLOCK["CLOCK"] -->|"component_of"| CIRCADIAN_CLOCK
BMAL1["BMAL1"] -->|"component_of"| CIRCADIAN_CLOCK| Target | Relation | Type | Str |
|---|---|---|---|
| Gene Expression | modulates | process | 0.95 |
| DNA Repair | modulates | process | 0.95 |
| Huntington's Disease | associated_with | disease | 0.95 |
| Sleep/Wake Cycles | regulates | phenotype | 0.95 |
| Biochemical Functions | associated_with | process | 0.95 |
| Physiologic Functions | associated_with | process | 0.95 |
| Behavioral Functions | associated_with | process | 0.95 |
| Cell Division | modulates | process | 0.95 |
| Alzheimer's Disease | associated_with | disease | 0.95 |
| Parkinson's Disease | associated_with | disease | 0.95 |
| Inflammation | regulates | process | 0.95 |
| Neurodegeneration | regulates | disease | 0.95 |
| Dna Repair | modulates | process | 0.95 |
| Hormone Release | regulates | process | 0.90 |
| Immune Response | regulates | process | 0.90 |
| Endothelial Cell | expressed_in | cell_type | 0.90 |
| Adiposity | regulates | phenotype | 0.89 |
| Gastroenterology | involved_in | process | 0.88 |
| food intake | regulates | process | 0.88 |
| Antioxidant Production | regulates | process | 0.85 |
| Brain Function | regulates | process | 0.85 |
| Central Immune Cells | regulates | cell_type | 0.85 |
| Peripheral Immune Cells | regulates | cell_type | 0.85 |
| Cellular Metabolism | modulates | process | 0.85 |
| Brain Cells | regulates | cell_type | 0.85 |
| phospholipid metabolism | modulates | process | 0.85 |
| insulin resistance | contributes_to | phenotype | 0.85 |
| Metabolic Syndrome | regulates | disease | 0.85 |
| Angiogenesis | regulates | process | 0.80 |
| CANCER | predisposes | disease | 0.80 |
| Atherosclerosis | implicated_in | disease | 0.80 |
| tumor genesis | involved_in | process | 0.65 |
| tumor progression | involved_in | process | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NIGHT-TIME LIGHT EXPOSURE | associated_with | entity | 0.90 |
| SHIFT WORK | associated_with | entity | 0.90 |
| MISTIMED EATING | associated_with | entity | 0.90 |
| SOCIAL JET LAG | associated_with | entity | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Circadian Clock-Autophagy Synchronization | 0.547 | neurodegeneration | Sleep disruption as cause and consequenc |
| Temporal Decoupling via Circadian Clock Reset | 0.516 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Heal [PMID:40588189] | Bishehsari F, Post Z, Swanson GR, Keshav | Gastroenterology | 2025 | 1 |
| From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404] | Kroemer G, Maier AB, Cuervo AM, Gladyshe | Cell | 2025 | 1 |
| Circadian disruption, clock genes, and metabolic health. [PMID:39007272] | Schrader LA, Ronnekleiv-Kelly SM, Hogene | J Clin Invest | 2024 | 1 |
| Biomarkers of aging for the identification and evaluation of longevity intervent [PMID:37657418] | Moqri M, Herzog C, Poganik JR, Biomarker | Cell | 2023 | 1 |
| Clocks, cancer, and chronochemotherapy. [PMID:33384351] | Sancar A, Van Gelder RN | Science | 2021 | 1 |
| Improved T-cell Receptor Diversity Estimates Associate with Survival and Respons [PMID:33177107] | Bortone DS, Woodcock MG, Parker JS, Vinc | Cancer Immunol Res | 2021 | 1 |
| Spatiotemporal profile of postsynaptic interactomes integrates components of com [PMID:28671696] | Li J, Zhang W, Yang H, Howrigan DP, Wilk | Nat Neurosci | 2017 | 1 |
| Core Concept: The Internet of Things and the explosion of interconnectivity. [PMID:27702874] | Ornes S | Proc Natl Acad Sci U S A | 2016 | 1 |
| Epigenetics and the gut-brain axis: Insights into DNA methylation, aging, and Al [PMID:41886887] | Kumar V, Shukla R, Gangani S, Joseph R, | The Journal of pharmacology an | 2026 | 0 |
| Effects of circadian rhythms on antimicrobial peptide concentrations in lactatin [PMID:41923233] | Liang ZL, Nii T, Sugino T, Isobe N | BMC veterinary research | 2026 | 0 |
| Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646] | Lin L, Liang X, Xu Z, Li Y, Guo Z et al. | Biomaterials | 2026 | 0 |
| Pharmacological modulation of circadian rhythms in brain microvasculature. [PMID:41355044] | Yang Z, Kim M, Montgomery M, Lewandowski | J Cereb Blood Flow Metab | 2026 | 0 |
| The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525] | Sica V, Sato T, Tsialtas I, Hernandez S, | J Biol Rhythms | 2026 | 0 |
| When Clocks Go Rogue: Circadian Rhythms and the Rise of Cancer. [PMID:41520235] | Robinson AS, Bennett S, Sato S | J Biol Rhythms | 2026 | 0 |
| Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008] | Tsameret S, Froy O, Matz Y, Landau Z, Tw | Diabetologia | 2026 | 0 |
| Circadian locomotor activity-rest rhythm in Drosophila is regulated by microRNA- [PMID:41632758] | Anna G, Tharayil Jayalal N, Jayan A, Ran | Genetics | 2026 | 0 |
| Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and lo [PMID:41763011] | Shan J, Tay JH, Ye KX, Guo J, Cao L et a | J Prev Alzheimers Dis | 2026 | 0 |
| Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses [PMID:41785851] | Zhao H, Liao M, Huo R, He T, Tian H et a | Cell | 2026 | 0 |
| Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987] | Al Saeedy DY, Hawkins E, Dozmorov MG, Tr | J Mol Neurosci | 2026 | 0 |
| Integrative Dermatology for Longevity: The Synergy of Topical and Internal Appro [PMID:41926038] | Haykal D, Flament F, Balooch G, Mora P, | Dermatol Ther (Heidelb) | 2026 | 0 |