Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about INSULIN RESISTANCE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
INSULIN RESISTANCE is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 852 entities in the SciDEX knowledge graph.
| Name | INSULIN RESISTANCE |
| Key Genes/Proteins | INFLAMMATION |
| Related Diseases | Als, Obesity, Inflammation, Diabetes, Alzheimer |
| Related Pathways | Oxidative Stress |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
INSULIN_RESISTANCE["INSULIN RESISTANCE"]
INSULIN_RESISTANCE -->|"inhibits"| PI3K_Akt_mTOR_pathway["PI3K/Akt/mTOR pathway"]
INSULIN_RESISTANCE -->|"contributes to"| AGEs["AGEs"]
INSULIN_RESISTANCE -->|"causes"| neurodegeneration["neurodegeneration"]
INSULIN_RESISTANCE -->|"activates"| Parkinson_s_disease["Parkinson's disease"]
INSULIN_RESISTANCE -->|"activates"| Alzheimer_s_disease["Alzheimer's disease"]
INSULIN_RESISTANCE -->|"activates"| brain_aging["brain aging"]
INSULIN_RESISTANCE -->|"target for"| Carcinoma["Carcinoma"]
PI3K_Akt_mTOR_pathway -->|"causes"| INSULIN_RESISTANCE
lycorine["lycorine"] -->|"treats"| INSULIN_RESISTANCE
resveratrol["resveratrol"] -.protects against.-> INSULIN_RESISTANCE
Tirzepatide["Tirzepatide"] -.protects against.-> INSULIN_RESISTANCE
SCP_oil["SCP-oil"] -->|"inhibits"| INSULIN_RESISTANCE
PI3K_AKT_pathway["PI3K/AKT pathway"] -->|"regulates"| INSULIN_RESISTANCE| Target | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 1.00 |
| Obesity | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Obesity | associated_with | disease | 1.00 |
| Metabolic Syndrome | activates | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Diabetes | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Lipid Metabolism | activates | pathway | 1.00 |
| Insulin Signaling | activates | pathway | 1.00 |
| Hypertension | associated_with | disease | 1.00 |
| Metabolic Syndrome | associated_with | disease | 1.00 |
| Type 2 Diabetes | associated_with | disease | 1.00 |
| Insulin Resistance | contributes_to | disease | 1.00 |
| Insulin Resistance | activates | disease | 1.00 |
| PI3K | activates | gene | 1.00 |
| Insulin Resistance | associated_with | disease | 1.00 |
| Fatty Liver | activates | disease | 1.00 |
| Diabetes | implicated_in | disease | 1.00 |
| Als | implicated_in | disease | 1.00 |
| Insulin Resistance | inhibits | disease | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| EXERCISE | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| Type 2 Diabetes | activates | disease | 1.00 |
| Insulin Resistance | therapeutic_target | disease | 1.00 |
| Type 2 Diabetes | therapeutic_target | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| Inflammation | regulates | disease | 0.95 |
| Fibrosis | therapeutic_target | disease | 0.95 |
| Cardiovascular | activates | disease | 0.95 |
| Obesity | inhibits | disease | 0.95 |
| Als | associated_with | disease | 0.95 |
| Aging | therapeutic_target | disease | 0.95 |
| Alzheimer | therapeutic_target | disease | 0.95 |
| Diabetes | contributes_to | disease | 0.95 |
| Aging | activates | disease | 0.95 |
| Insulin Resistance | causes | disease | 0.95 |
| Inflammation | treats | disease | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 0.90 |
| SIRT1 | activates | gene | 0.90 |
| MITOPHAGY | activates | gene | 0.90 |
| INFLAMMATION | associated_with | gene | 0.90 |
| APOPTOSIS | implicated_in | gene | 0.90 |
| DIABETES MELLITUS | associated_with | gene | 0.80 |
| TAU | activates | gene | 0.80 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.80 |
| AKT | inhibits | gene | 0.80 |
| INFLAMMATION | contributes_to | gene | 0.80 |
| AGING | activates | gene | 0.80 |
| CLOCK | associated_with | entity | 0.75 |
| AUTOPHAGY | regulates | gene | 0.70 |
| AUTOPHAGY | activates | gene | 0.70 |
| INFLAMMATION | therapeutic_target | gene | 0.70 |
| AUTOPHAGY | therapeutic_target | gene | 0.70 |
| NF-ΚB | activates | gene | 0.70 |
| ALZHEIMER'S DISEASE | activates | gene | 0.70 |
| OXIDATIVE STRESS | activates | gene | 0.70 |
| CIRCADIAN RHYTHM | activates | gene | 0.70 |
| IL-6 | inhibits | gene | 0.70 |
| NRF2 | activates | gene | 0.70 |
| DIABETES MELLITUS | therapeutic_target | gene | 0.70 |
| APOPTOSIS | inhibits | gene | 0.70 |
| OXIDATIVE STRESS | associated_with | gene | 0.70 |
| NEURODEGENERATION | associated_with | gene | 0.70 |
| ERK | therapeutic_target | gene | 0.70 |
| APOPTOSIS | therapeutic_target | gene | 0.70 |
| AUTOPHAGY | associated_with | gene | 0.70 |
| ROS | inhibits | gene | 0.70 |
| BAX | inhibits | gene | 0.70 |
| ATP | activates | gene | 0.70 |
| NEURODEGENERATION | contributes_to | gene | 0.70 |
| AUTOPHAGY | contributes_to | gene | 0.70 |
| ROS | associated_with | gene | 0.70 |
| MITOCHONDRIA | regulates | gene | 0.70 |
| AUTOPHAGY | implicated_in | gene | 0.70 |
| APOPTOSIS | treats | gene | 0.70 |
| ROS | treats | gene | 0.70 |
| EPILEPSY | activates | gene | 0.70 |
| NEURODEGENERATION | therapeutic_target | gene | 0.70 |
| TNF | activates | gene | 0.70 |
| NEURODEGENERATION | activates | gene | 0.70 |
| PARKINSON | activates | gene | 0.70 |
| IL-6 | activates | gene | 0.70 |
| APOPTOSIS | associated_with | gene | 0.70 |
| LIPID METABOLISM | treats | phenotype | 0.70 |
| NEURONS | activates | cell_type | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Brain Insulin Resistance with Glucose Transporter Dysfunctio | 0.398 | neurodegeneration | Metabolic reprogramming in neurodegenera |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Comparative study of the glucolipid profile and GLUTs gene expression in respons [PMID:41232212] | ["Wang Z", "Wang H", "Du P", "Zhang X", | Poultry science | 2025 | 0 |
| Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy an [PMID:41369048] | ["Xu W", "Neal E", "Barlow N", "Thompson | Journal of neurochemistry | 2025 | 0 |
| Targeting glucose transporters in parkinson's disease: a novel metabolic approac [PMID:40879857] | ["Singh G", "Ansari S", "Aran K"] | Metabolic brain disease | 2025 | 0 |
| Tirzepatide prevents neurodegeneration through multiple molecular pathways. [PMID:38287296] | Fontanella RA, Ghosh P, Pesapane A, Takt | Journal of translational medic | 2024 | 0 |
| A high fat diet potentiates neonatal iron overload-induced memory impairments in [PMID:38358514] | ["do Nascimento F", "de Freitas B", "Dos | European journal of nutrition | 2024 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582] | Yadav P, Antony-Babu S, Hayes E, Healy O | Microbiology resource announce | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |