disease

drpla

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about drpla: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

0Analyses

23Outgoing

3Incoming

0Experiments

0Debates

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Disease Info

Juvenile-onset DRPLA	onset before 20 years, typically associated with 65-88 repeats
Adult-onset DRPLA	onset after 20 years, typically associated with 48-60 repeats
Dentatorubral degeneration	degeneration of the dentate nucleus in the cerebellum and the red nucleus in the midbrain
Pallidoluysian degeneration	degeneration of the globus pallidus and the subthalamic nucleus
Loss of Purkinje cells	in the cerebellar cortex
Neuronal loss and gliosis	throughout the cerebellum, brainstem, and basal ganglia
KG Connections	5 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

🔮 Predicted Structure: drpla — AlphaFold P55072 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Dentatorubral-Pallidoluysian Atrophy (DRPLA)

disease · 2861 words

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Pathway Diagram

graph TD
    DRPLA["DRPLA"]
    DRPLA -->|"expressed in"| Als["Als"]
    DRPLA -->|"causes"| Huntington["Huntington"]
    DRPLA -->|"expressed in"| ALS["ALS"]
    DRPLA -->|"causes"| HUNTINGTON["HUNTINGTON"]
    DRPLA -->|"expressed in"| T_Cell["T Cell"]
    DRPLA -->|"expressed in"| Neuron["Neuron"]
    DRPLA -->|"causes"| HUNTINGTON_S_DISEASE["HUNTINGTON'S DISEASE"]
    DRPLA -->|"causes"| AND["AND"]
    HUNTINGTON -->|"causes"| DRPLA

Outgoing (23)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:DRPLA	data_in	dataset_row	0.00
Als	expressed_in	disease	0.65
Huntington	causes	disease	0.65
ALS	expressed_in	disease	0.65
T Cell	expressed_in	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
HUNTINGTON'S DISEASE	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
autophagy pathway	participates_in	pathway	0.60
Rb	expressed_in	protein	0.60
HUNTINGTON	causes	gene	0.60
HUNTINGTIN	associated_with	gene	0.60
Protein Aggregation	expressed_in	pathway	0.60
Huntingtin	associated_with	protein	0.60
oxidative stress response	participates_in	pathway	0.60
Huntington's disease	causes	disease	0.60
Fus	expressed_in	protein	0.60
neurodegeneration	inhibits	disease	0.60
HUNTINGTON	causes	gene	0.50
HUNTINGTON'S DISEASE	causes	concept	0.50
disease	causes	disease	0.50
HUNTINGTON'S	causes	concept	0.50
HUNTINGTIN	associated_with	protein	0.50

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:DRPLA	data_in	dataset_row	0.00
HUNTINGTIN	associated_with	gene	0.60
HUNTINGTON	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning drpla in their description or question text

No additional research found