protein

HUNTINGTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUNTINGTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

860Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HUNTINGTIN is a protein involved in neurodegeneration research. Key relationships include: associated with, contributes to, regulates. Associated with ALS, Aging, Als. Connected to 136 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HUNTINGTIN
Full Name	Huntingtin (HTT)
Protein Type	Protein
Function	is a large protein encoded by the HTT gene, most famous for its role in Huntington's disease where CAG repeat expansion in the first exon leads to mutant huntingtin (mHTT).
Molecular Weight	350 kDa
Amino Acids	144 aa
Pathways	NF-κB
UniProt ID	Search UniProt
GeneCards	HUNTINGTIN
Human Protein Atlas	HUNTINGTIN
Associated Diseases	ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	RAPAMYCIN
Interactions	CGAS, STING, MTOR, LC3, HTT, BDNF
KG Connections	691 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HUNTINGTIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HUNTINGTIN["HUNTINGTIN"]
    HUNTINGTIN -->|"regulates"| BDNF["BDNF"]
    HUNTINGTIN -->|"regulates"| BDNF_synthesis["BDNF synthesis"]
    HUNTINGTIN -->|"regulates"| BDNF_transport["BDNF transport"]
    HUNTINGTIN -->|"causes"| Huntington_s_disease["Huntington's disease"]
    HUNTINGTIN -->|"expressed in"| cerebrospinal_fluid["cerebrospinal fluid"]
    HUNTINGTIN -->|"regulates"| Aging["Aging"]
    HUNTINGTIN -->|"regulates"| Alzheimer["Alzheimer"]
    HUNTINGTIN -->|"regulates"| Parkinson["Parkinson"]
    HUNTINGTIN -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    HUNTINGTIN -->|"regulates"| Stroke["Stroke"]
    HTT["HTT"] -->|"encodes"| HUNTINGTIN
    antisense_oligonucleotides["antisense oligonucleotides"] -->|"inhibits"| HUNTINGTIN
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"regulates"| HUNTINGTIN
    BCL_2["BCL-2"] -->|"regulates"| HUNTINGTIN
    STROKE["STROKE"] -->|"regulates"| HUNTINGTIN
    MITOCHONDRIA["MITOCHONDRIA"] -->|"regulates"| HUNTINGTIN
    PRESENILIN_1["PRESENILIN-1"] -->|"regulates"| HUNTINGTIN
    PRESENILIN["PRESENILIN"] -->|"regulates"| HUNTINGTIN
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| HUNTINGTIN
    EXERCISE["EXERCISE"] -->|"regulates"| HUNTINGTIN

Outgoing (523)

Target	Relation	Type	Str
BDNF	transports	gene	0.90
polyglutamine	aggregates_with	compound	0.80
DNA damage response	regulates	process	0.80
chromatin remodeling	regulates	process	0.80
RNA processing	regulates	process	0.80
Huntington's disease	implicated_in	disease	0.80
AUTOPHAGY	inhibits	phenotype	0.70
AUTOPHAGY	treats	phenotype	0.70
Spinal Muscular Atrophy	associated_with	disease	0.65
PINK1	degrades	gene	0.65
ALS	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Stroke	regulates	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
Multiple Sclerosis	contributes_to	disease	0.65
ALS	contributes_to	disease	0.65
Huntington	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.65
Parkinson	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Huntington	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	causes	disease	0.65
Huntington	causes	disease	0.65
Huntington	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Ms	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Ataxia	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65

Incoming (337)

Source	Relation	Type	Str
DNAJB1	causes	gene	0.65
KYNURENINE	interacts_with	phenotype	0.65
FUS	regulates	gene	0.65
HUNTINGTON'S DISEASE	targets	disease	0.65
HUNTINGTON'S DISEASE	encodes	disease	0.65
SMN1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
P62	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
HTT	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
SETX	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
PRESENILIN-1	regulates	gene	0.60
SOD1	contributes_to	gene	0.60
TAU	contributes_to	gene	0.60
GABARAP	associated_with	gene	0.60
ALS4	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
MLH1	activates	gene	0.60
ACTB	activates	entity	0.60
ALS4	activates	entity	0.60
ATG7	activates	entity	0.60
BECN1	activates	entity	0.60
DNMT1	activates	entity	0.60
GABARAP	activates	entity	0.60
HTT	activates	entity	0.60
HTT	causes	entity	0.60
FKBP1A	inhibits	gene	0.60
TAU	therapeutic_target	gene	0.60
C1Q	expressed_in	gene	0.60
NEAT1	associated_with	gene	0.60
TAU	associated_with	gene	0.60
BDNF	therapeutic_target	gene	0.60
HTT	expressed_in	gene	0.60
DNAJB6	interacts_with	gene	0.60
CDK4	inhibits	gene	0.60
JNK	inhibits	gene	0.60
HDAC4	inhibits	gene	0.60
CDK2	inhibits	gene	0.60
HTT	inhibits	gene	0.60
DRPLA	associated_with	gene	0.60
MTOR	inhibits	gene	0.60
FKBP5	regulates	gene	0.60
HTT	therapeutic_target	gene	0.60
RAB7	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HUNTINGTIN

Understanding Entity Pages

Summary

Wiki Pages (21)

Huntingtin (HTT)

Novel Therapy Index

Parkinson's Disease

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

NPM1 Gene

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Oligodendrocytes

oxidative-stress-comparison

Neurotrophin Signaling Pathways in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

gabaergic-dysfunction

CNTN6 — Contactin 6

Huntington's Disease

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases