protein

Huntingtin

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Huntingtin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

860Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	HUNTINGTIN
Full Name	Huntingtin (HTT)
Protein Type	Protein
Function	is a large protein encoded by the HTT gene, most famous for its role in Huntington's disease where CAG repeat expansion in the first exon leads to mutant huntingtin (mHTT).
Molecular Weight	350 kDa
Amino Acids	144 aa
Pathways	NF-κB
UniProt ID	Search UniProt
GeneCards	HUNTINGTIN
Human Protein Atlas	HUNTINGTIN
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Huntington, Huntington'S Disease
Interactions	HUNTINGTIN, GSK3, CDK2, C-JUN, HDAC4, DNAJB6
KG Connections	157 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Huntingtin["Huntingtin"] -->|"promotes"| Tau_Pathology["Tau Pathology"]
    style Tau_Pathology fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Huntingtin["Huntingtin"] -->|"associated"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    style Frontotemporal_Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Huntingtin["Huntingtin"] -->|"associated"| Dementia["Dementia"]
    style Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Huntingtin["Huntingtin"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    style Amyotrophic_Lateral_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Huntingtin["Huntingtin"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Huntingtin["Huntingtin"] -->|"regulates"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Huntingtin["Huntingtin"] -->|"regulates"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TAU["TAU"] -->|"interacts"| Huntingtin["Huntingtin"]
    style TAU fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    NEURON["NEURON"] -->|"associated"| Huntingtin["Huntingtin"]
    style NEURON fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TFEB["TFEB"] -->|"associated"| Huntingtin["Huntingtin"]
    style TFEB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SMN1["SMN1"] -->|"associated"| Huntingtin["Huntingtin"]
    style SMN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"associated"| Huntingtin["Huntingtin"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Huntingtin fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (523)

Target	Relation	Type	Str
Tau Pathology	promotes	mechanism	0.85
Huntington'S Disease	causes	disease	0.80
Protein Aggregation	causes	mechanism	0.80
Frontotemporal Dementia	associated_with	disease	0.60
Dementia	associated_with	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Als	associated_with	disease	0.60
Alzheimer	regulates	disease	0.60
Aging	regulates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Stroke	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Huntington	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Als	stabilizes	disease	0.60
Huntington	causes	disease	0.60
Als	inhibits	disease	0.60
Huntington	associated_with	disease	0.60
Huntington	stabilizes	disease	0.60
Neurodegeneration	stabilizes	disease	0.60
Als	causes	disease	0.60
Dementia	contributes_to	disease	0.60
Neurodegeneration	contributes_to	disease	0.60
Huntington	contributes_to	disease	0.60
Aging	therapeutic_target	disease	0.60
Als	regulates	disease	0.60
Als	contributes_to	disease	0.60
Huntington	regulates	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60
Autophagy	associated_with	pathway	0.55
Mtor	associated_with	pathway	0.55
Oxidative Stress	associated_with	pathway	0.55
Oxidative Stress	therapeutic_target	pathway	0.55
Apoptosis	therapeutic_target	pathway	0.55
Dna Repair	associated_with	pathway	0.55
Cholesterol	therapeutic_target	pathway	0.55
Cell Cycle	inhibits	pathway	0.55
Dna Methylation	contributes_to	pathway	0.55
Histone Modification	contributes_to	pathway	0.55
Epigenetic	contributes_to	pathway	0.55
Autophagy	stabilizes	pathway	0.55
Dna Repair	interacts_with	pathway	0.55

Incoming (337)

Source	Relation	Type	Str
TAU	interacts_with	protein	0.90
NEURON	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
SMN1	associated_with	gene	0.60
ALS	associated_with	gene	0.60
HTT	associated_with	gene	0.60
DNMT1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
SETX	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HUNTINGTIN	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
STROKE	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AMYLOID	associated_with	gene	0.60
HUNTINGTIN	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
BCL-2	regulates	gene	0.60
PRESENILIN-1	regulates	gene	0.60
AGING	regulates	gene	0.60
NEURON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
HUNTINGTIN	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
SOD1	therapeutic_target	gene	0.60
HUNTINGTIN	therapeutic_target	gene	0.60
HTT	causes	gene	0.60
MICROGLIA	expressed_in	gene	0.60
HUNTINGTON	expressed_in	gene	0.60
HUNTINGTIN	expressed_in	gene	0.60
C1Q	expressed_in	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
SYNAPSE	expressed_in	gene	0.60
NEAT1	stabilizes	gene	0.60
TAU	stabilizes	gene	0.60
ALS	stabilizes	gene	0.60
LNCRNA	therapeutic_target	gene	0.60
HUNTINGTIN	stabilizes	gene	0.60
NEURON	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Huntingtin

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Parkinson's Disease

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

NPM1 Gene

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Oligodendrocytes

oxidative-stress-comparison

Neurotrophin Signaling Pathways in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

gabaergic-dysfunction

CNTN6 — Contactin 6

Huntington's Disease

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases