Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TREM2 |
| Full Name | PROTEIN |
| Aliases | Triggering Receptor Expressed on Myeloid cells 2, TREM-2 |
| Chromosome | 6p21.1 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | Lipid sensing; Debris clearance; Microglial activation |
| Mechanism of Action | Agonist antibodies that enhance TREM2 signaling to promote microglial function |
| Primary Expression | Microglia, Cerebral cortex, Hippocampus |
| Druggability | Low (0.42) |
| Clinical Stage | Phase II |
| Molecular Weight | 35 kDa |
| Amino Acids | 231 aa |
| Exons | 5 |
| Pathways | Innate immunity, Phagocytosis, DAP12-SYK signaling |
| UniProt ID | Q9NZC2 |
| NCBI Gene ID | 54209 |
| Ensembl ID | ENSG00000095970 |
| OMIM | 605086 |
| GeneCards | TREM2 |
| Human Protein Atlas | TREM2 |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, ALZHEIMERS, AUTOPHAGY, Aging |
| Known Drugs/Compounds | lecanemab treatment, β-amyloid, phosphatidylserine, amyloid deposits, METFORMIN, Beta-Amyloid |
| Interactions | NLRP3, TLR4, GSDMD, MYD88, CD9, PSEN1 |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | TREM2-Dependent Microglial Senescence Transition TREM2-Dependent Astrocyte-Microglia Cross-talk in TREM2-Dependent Microglial Phagocytosis Acts as a (+31 more) |
| KG Connections | 3620 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["TREM2 PROTEIN"]
N1["ALZHEIMER"]
N0 -->|"activates"| N1
N2["Alzheimer'S Disease"]
N0 -->|"activates"| N2
N3["disease"]
N0 -->|"activates"| N3
N4["ALZHEIMER'S"]
N0 -->|"activates"| N4
N5["Cortex"]
N0 -.->|"inhibits"| N5
N6["Hippocampus"]
N0 -.->|"inhibits"| N6
N7["FRONTAL"]
N0 -.->|"inhibits"| N7
N8["TREM2"]
N8 -->|"activates"| N0
N9["late"]
N9 -->|"activates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 gene
class N2 disease
class N3 disease
class N8 gene
class N9 disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||