concept

FRONTOTEMPORAL LOBAR DEGENERATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTOTEMPORAL LOBAR DEGENERATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

0Outgoing

23Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	FRONTOTEMPORAL LOBAR DEGENERATION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FRONTOTEMPORAL_LOBAR_DEGENERAT["FRONTOTEMPORAL LOBAR DEGENERATION"]
    TDP_43_Pathology["TDP-43 Pathology"] -.biomarker for.-> FRONTOTEMPORAL_LOBAR_DEGENERAT
    SQSTM1["SQSTM1"] -->|"risk_factor_for"| FRONTOTEMPORAL_LOBAR_DEGENERAT
    C9ORF72["C9ORF72"] -->|"causes"| FRONTOTEMPORAL_LOBAR_DEGENERAT
    TDP_43["TDP-43"] -.biomarker for.-> FRONTOTEMPORAL_LOBAR_DEGENERAT
    ULK1["ULK1"] -.biomarker for.-> FRONTOTEMPORAL_LOBAR_DEGENERAT
    Neuronal_Inclusion_Bodies["Neuronal Inclusion Bodies"] -.biomarker for.-> FRONTOTEMPORAL_LOBAR_DEGENERAT

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (23)

Source	Relation	Type	Str
TDP-43 Pathology	biomarker_for	biomarker	0.95
TDP-43	associated_with	protein	0.95
TDP43	associated_with	protein	0.95
SQSTM1	risk_factor_for	gene	0.95
C9ORF72	causes	gene	0.95
C9ORF72	risk_factor_for	gene	0.95
TDP-43	biomarker_for	protein	0.95
TARDBP	associated_with	protein	0.95
GRN	risk_factor_for	gene	0.95
ULK1	biomarker_for	protein	0.92
Neuronal Inclusion Bodies	biomarker_for	biomarker	0.90
TDP-43	implicated_in	protein	0.90
C9ORF72	associated_with	gene	0.90
Astroglial Pathology	contributes_to	mechanism	0.90
TDP-43 proteinopathy	involved_in	process	0.90
Tdp-43 Inclusions	associated_with	pathology	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.88
P62	biomarker_for	protein	0.80
GRN	associated_with	gene	0.70
TDP-43	biomarker_for	protein	0.70
FUS	associated_with	protein	0.60
GRN	causes	gene	0.60
TBK1	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FRONTOTEMPORAL LOBAR DEGENERATION

Understanding Entity Pages

Wiki Pages (20)

Corticobasal Syndrome (CBS)

primary-progressive-aphasia

Corticobasal Degeneration (CBD)

Frontotemporal Dementia (FTD)

CBS/PSP Clinical Trials Guide

ftd-tdp-pathology

gabaergic-dysfunction

Splice-Modulating Therapies for Neurodegeneration

cognitive-reserve-cbs-psp

TDP-43 Proteinopathy

Tauopathies

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Motor Neuron Disease (MND)

Beta-Amyloid 42/40 Ratio - Biomarker

Disease Progression and Staging in Progressive Supranuclear Palsy

Tau Pathology Pathway in Frontotemporal Dementia

semantic-dementia

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis